ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Ventral premotor-motor cortex interactions in the macaque monkey during grasp: response of single neurons to intracortical microstimulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Disentangling indirect versus direct effects of somatosensory cortex microstimulation on neurons in primary motor and ventral premotor cortex.Journal of neural engineering · 2025Article
- Training-Free Regulation of Grasping by Intracortical Tactile Feedback Designed via S1-M1 Communication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Low frequency independent components: Internal neuromarkers linking cortical LFPs to behavior.iScience · 2024Article
- Reduced Cerebellar Brain Inhibition and Vibrotactile Perception in Response to Mechanical Hand Stimulation at Flutter Frequency.Cerebellum (London, England) · 2024Article
- Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex.Nature communications · 2023Article
- A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming.Nature communications · 2022Article
- Increasing and decreasing interregional brain coupling increases and decreases oscillatory activity in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Movement initiation and grasp representation in premotor and primary motor cortex mirror neurons.eLife · 2020Article
- Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Direct Electrical Stimulation of Premotor Areas: Different Effects on Hand Muscle Activity during Object Manipulation.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Disconnected and Hyperactive: A Replication of Sensorimotor Cortex Abnormalities in Patients With Schizophrenia During Proactive Response Inhibition.Schizophrenia bulletin · 2019Article
- In vitro characterization of intrinsic properties and local synaptic inputs to pyramidal neurons in macaque primary motor cortex.The European journal of neuroscience · 2018Article
- Modulatory Effects of the Ipsi and Contralateral Ventral Premotor Cortex (PMv) on the Primary Motor Cortex (M1) Outputs to Intrinsic Hand and Forearm Muscles in Cebus apella.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Proactive response inhibition abnormalities in the sensorimotor cortex of patients with schizophrenia.Journal of psychiatry & neuroscience : JPN · 2016Article
- A Mixed-Signal VLSI System for Producing Temporally Adapting Intraspinal Microstimulation Patterns for Locomotion.IEEE transactions on biomedical circuits and systems · 2016Article
- Article
- Mapping Horizontal Spread of Activity in Monkey Motor Cortex Using Single Pulse Microstimulation.Frontiers in neural circuits · 2016Article
- The dorsal premotor cortex exerts a powerful and specific inhibitory effect on the ipsilateral corticofacial system: a dual-coil transcranial magnetic stimulation study.Experimental brain research · 2015Article
- The mirror neuron system and the strange case of Broca's area.Human brain mapping · 2015Article
- Effective connectivity of depth-structure-selective patches in the lateral bank of the macaque intraparietal sulcus.PLoS biology · 2015Article
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Authors and funding
5 authors.
Funding
Abstract
Recent stimulation studies in monkeys and humans have shown strong interactions between ventral premotor cortex (area F5) and the hand area of primary motor cortex (M1). These short-latency interactions usually involve facilitation from F5 of M1 outputs to hand muscles, although suppression has also been reported. This study, performed in three awake macaque monkeys, sought evidence that these interactions could be mediated by short-latency excitatory and inhibitory responses of single M1 neurons active during grasping tasks. We recorded responses of these M1 neurons to single low-threshold (≤40 μA) intracortical microstimuli delivered to F5 sites at which grasp-related neurons were recorded. In 29 sessions, we tested 232 M1 neurons with stimuli delivered to between one and four sites in F5. Of the 415 responses recorded, 142 (34%) showed significant effects. The most common type of response was pure excitation (53% of responses), with short latency (1.8-3.0 ms) and brief duration (∼1 ms); purely inhibitory responses had slightly longer latencies (2-5 ms) and were of small amplitude and longer duration (5-7 ms). They accounted for 13% of responses, whereas mixed excitation then inhibition was seen in 34%. Remarkably, a rather similar set of findings applied to 280 responses of 138 F5 neurons to M1 stimulation; 109 (34%) responses showed significant effects. Thus, with low-intensity stimuli, the dominant interaction between these two cortical areas is one of short-latency, brief excitation, most likely mediated by reciprocal F5-M1 connections. Some neurons were tested with stimuli at both 20 and 40 μA; inhibition tended to dominate at the higher intensity.
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