ArticleAmerican journal of physiology. Renal physiology2011
Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells.
Article in American journal of physiology. Renal physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- EGFR-ErbB2 dual kinase inhibitor lapatinib decreases autoantibody levels and worsens renal disease in Interferon α-accelerated murine lupus.International immunopharmacology · 2024Article
- Compartmentalized ciliation changes of oligodendrocytes in aged mouse optic nerve.Journal of neuroscience research · 2024Article
- Prevalence, Risk Factors, Pathophysiology, Potential Biomarkers and Management of Feline Idiopathic Cystitis: An Update Review.Frontiers in veterinary science · 2022Review
- Galectin-7 in Epithelial Homeostasis and Carcinomas.International journal of molecular sciences · 2017Review
- Galectin-7 promotes the invasiveness of human oral squamous cell carcinoma cells via activation of ERK and JNK signaling.Oncology letters · 2017Article
- High expression of galectin-7 associates with poor overall survival in patients with non-metastatic clear-cell renal cell carcinoma.Oncotarget · 2016Article
- Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells.American journal of physiology. Renal physiology · 2016Article
- Increased cell proliferation and differential protein expression induced by low-level Er:YAG laser irradiation in human gingival fibroblasts: proteomic analysis.Lasers in medical science · 2015Article
- Examination of galectin localization using confocal microscopy.Methods in molecular biology (Clifton, N.J.) · 2015Article
- A Mutation in the Carbohydrate Recognition Domain Drives a Phenotypic Switch in the Role of Galectin-7 in Prostate Cancer.PloS one · 2015Article
- Role of galectins in re-epithelialization of wounds.Annals of translational medicine · 2014Review
- Article
- Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli.Cellular and molecular life sciences : CMLS · 2014Article
- Let's play a game of chutes and ladders: Lysosome fusion with the epithelial plasma membrane.Communicative & integrative biology · 2013Article
- Mechanism of polarized lysosome exocytosis in epithelial cells.Journal of cell science · 2012Article
- Apical targeting and endocytosis of the sialomucin endolyn are essential for establishment of zebrafish pronephric kidney function.Journal of cell science · 2012Article
- The extracellular matrix and ciliary signaling.Current opinion in cell biology · 2012Review
- Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism.Molecular biology of the cell · 2012Article
- Novel potential interacting partners of fibronectin in spontaneous animal model of interstitial cystitis.PloS one · 2012Article
- Axonemal positioning and orientation in three-dimensional space for primary cilia: what is known, what is assumed, and what needs clarification.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Galectins (Gal) are β-galactoside-binding proteins that function in epithelial development and homeostasis. An overlapping role for Gal-3 and Gal-7 in wound repair was reported in stratified epithelia. Although Gal-7 was thought absent in simple epithelia, it was reported in a proteomic analysis of cilia isolated from cultured human airway, and we recently identified Gal-7 transcripts in Madin-Darby canine kidney (MDCK) cells (Poland PA, Rondanino C, Kinlough CL, Heimburg-Molinaro J, Arthur CM, Stowell SR, Smith DF, Hughey RP. J Biol Chem 286: 6780-6790, 2011). We now report that Gal-7 is localized exclusively on the primary cilium of MDCK, LLC-PK(1) (pig kidney), and mpkCCD(c14) (mouse kidney) cells as well as on cilia in the rat renal proximal tubule. Gal-7 is also present on most cilia of multiciliated cells in human airway epithelia primary cultures. Interestingly, exogenous glutathione S-transferase (GST)-Gal-7 bound the MDCK apical plasma membrane as well as the cilium, while the lectin Ulex europeaus agglutinin, with glycan preferences similar to Gal-7, bound the basolateral plasma membrane as well as the cilium. In pull-down assays, β1-integrin isolated from either the basolateral or apical/cilia membranes of MDCK cells was similarly bound by GST-Gal-7. Selective localization of Gal-7 to cilia despite the presence of binding sites on all cell surfaces suggests that intracellular Gal-7 is specifically delivered to cilia rather than simply binding to surface glycoconjugates after generalized secretion. Moreover, depletion of Gal-7 using tetracycline-induced short-hairpin RNA in mpkCCD(c14) cells significantly reduced cilia length and slowed wound healing in a scratch assay. We conclude that Gal-7 is selectively targeted to cilia and plays a key role in surface stabilization of glycoconjugates responsible for integrating cilia function with epithelial repair.
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