ArticleJournal of the Royal Society, Interface2012
A composite computational model of liver glucose homeostasis. I. Building the composite model.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- A liver digital twin for in silico testing of cellular and inter-cellular mechanisms in regeneration after drug-induced damage.iScience · 2024Article
- Virtual metabolic human dynamic model for pathological analysis and therapy design for diabetes.iScience · 2021Article
- Computational Modeling of Fructose Metabolism and Development in NAFLD.Frontiers in bioengineering and biotechnology · 2020Article
- Model-based virtual patient analysis of human liver regeneration predicts critical perioperative factors controlling the dynamic mode of response to resection.BMC systems biology · 2019Article
- Computational Modeling in Liver Surgery.Frontiers in physiology · 2017Review
- A Computational Model of Hepatic Energy Metabolism: Understanding Zonated Damage and Steatosis in NAFLD.PLoS computational biology · 2016Article
- A computer model simulating human glucose absorption and metabolism in health and metabolic disease states.F1000Research · 2016Article
- A Kinetic-Model-Based Approach to Identify Malfunctioning Components in Signal Transduction Pathways from Artificial Clinical Data.BioMed research international · 2015Article
- A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System.CPT: pharmacometrics & systems pharmacology · 2013Article
- The impact of mathematical modeling on the understanding of diabetes and related complications.CPT: pharmacometrics & systems pharmacology · 2013Article
- A methodology for global-sensitivity analysis of time-dependent outputs in systems biology modelling.Journal of the Royal Society, Interface · 2012Article
- A composite computational model of liver glucose homeostasis. II. Exploring system behaviour.Journal of the Royal Society, Interface · 2012Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A computational model of the glucagon/insulin-driven liver glucohomeostasis function, focusing on the buffering of glucose into glycogen, has been developed. The model exemplifies an 'engineering' approach to modelling in systems biology, and was produced by linking together seven component models of separate aspects of the physiology. The component models use a variety of modelling paradigms and degrees of simplification. Model parameters were determined by an iterative hybrid of fitting to high-scale physiological data, and determination from small-scale in vitro experiments or molecular biological techniques. The component models were not originally designed for inclusion within such a composite model, but were integrated, with modification, using our published modelling software and computational frameworks. This approach facilitates the development of large and complex composite models, although, inevitably, some compromises must be made when composing the individual models. Composite models of this form have not previously been demonstrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.