ArticleThe Journal of antimicrobial chemotherapy2011
Increasing prevalence and dissemination of NDM-1 metallo-β-lactamase in India: data from the SMART study (2009).
Article in The Journal of antimicrobial chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
70 citing papers in PubMed, 165 citations in OpenAlex.
- Detection of blaJournal of clinical laboratory analysis · 2025Article
- Article
- Exploring New Delhi Metallo Beta Lactamases in Klebsiella pneumoniae and Escherichia coli: genotypic vs. phenotypic insights.Annals of clinical microbiology and antimicrobials · 2025Article
- Machine Learning Models Identify Inhibitors of New Delhi Metallo-β-lactamase.Journal of chemical information and modeling · 2024Article
- Detection of NDM-1 and OXA-10 Co-ProducingInfection and drug resistance · 2023Article
- Bacteriological characteristics of hypervirulentIranian journal of microbiology · 2022Article
- Enzyme Inhibitors: The Best Strategy to Tackle Superbug NDM-1 and Its Variants.International journal of molecular sciences · 2021Review
- Molecular epidemiology of carbapenem-resistant Enterobacterales in Thailand, 2016-2018.Antimicrobial resistance and infection control · 2021Article
- Genome-based characterization of two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases.BMC microbiology · 2020Article
- Coinfections of Two Strains of NDM-1- and OXA-232-Coproducing Klebsiella pneumoniae in a Kidney Transplant Patient.Antimicrobial agents and chemotherapy · 2020Article
- Treatment and Outcomes of Infections Caused by Diverse Carbapenemase-Producing Carbapenem-ResistantFrontiers in cellular and infection microbiology · 2020Article
- Molecular Characterization of Extended Spectrum β-lactamase and Carbapenemase ProducingIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
- Endemic dissemination of different sequence types of carbapenem-resistantInfection and drug resistance · 2019Article
- Prevalence and molecular epidemiology characteristics of carbapenem-resistantInfection and drug resistance · 2019Article
- Molecular detection ofMedical journal, Armed Forces India · 2018Article
- Colistin Versus Ceftazidime-Avibactam in the Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- Detection of Antibiotic Resistance Determinants and Their Transmissibility among Clinically Isolated Carbapenem-Resistant Escherichia coli from South India.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018Article
- CXC Chemokines Exhibit Bactericidal Activity against Multidrug-Resistant Gram-Negative Pathogens.mBio · 2017Article
- Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1.Journal of medicinal chemistry · 2017Article
- New Delhi metallo-β-lactamase - type carbapenemases producingThe Indian journal of medical research · 2017Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo investigate the β-lactamase background of ertapenem non-susceptible isolates for the presence of the most commonly detected carbapenemase genes, bla(KPC), bla(OXA-48) and bla(VIM), and the newly described bla(NDM-1).
methodsTwo hundred and thirty-five ertapenem-non-susceptible (MIC ≥ 0.5 mg/L) isolates of Enterobacteriaceae from the worldwide Study for Monitoring Antimicrobial Resistance Trends (SMART) 2009 programme were screened using a multiplex PCR for the presence of bla(KPC), bla(OXA-48), bla(VIM) and bla(NDM-1) genes. Extended-spectrum β-lactamase (ESBL) and AmpC genes (bla(ESBL) and bla(AmpC)) were identified using the Check-MDR CT101 microarray. DNA sequencing was performed to identify the bla(ESBL), bla(KPC) and bla(NDM-1) genes. Molecular typing was also performed to genetically characterize these isolates.
resultsSixty-six isolates (28%) had a carbapenemase gene, with bla(NDM-1) identified in 33 isolates including 2 isolates carrying both bla(NDM-1) and bla(OXA-48); other carbapenemase genes found included bla(KPC) (n = 23), bla(VIM) (n = 7) and bla(OXA-48) (n = 3). All bla(NDM-1)-carrying isolates were from patients in India and comprised five different species. With the exception of one isolate carrying only bla(NDM-1), all bla(NDM-1) carbapenemase-possessing isolates carried additional β-lactamases in various combinations: bla(ESBL) and bla(AmpC) (n = 18); bla(ESBL) (n = 10); bla(ESBL), bla(AmpC) and bla(OXA-48) (n = 2); and bla(AmpC) (n = 2). Except for bla(OXA-48)-carrying isolates, novel multilocus sequence types or enterobacterial repetitive intergenic consensus PCR patterns were observed along with clonal dissemination within and among sites.
conclusionsA range of carbapenemase genes, associated with diverse ESBLs and/or AmpC backgrounds, were found among Enterobacteriaceae isolated during the study. Many of these ertapenem non-susceptible strains were clonally related and carried various combinations of β-lactamases.
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