ArticleDrug and alcohol dependence2011
Injection methamphetamine use is associated with an increased risk of attempted suicide: a prospective cohort study.
Article in Drug and alcohol dependence, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Suicide and psychiatric disorders associated with amphetamine type stimulant use: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Methamphetamine alters nucleus accumbens neural activation to monetary loss in healthy young adults.Psychopharmacology · 2023Trial
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- Impulsive suicide in methamphetamine intoxication and self-reported ADHD: a case report.Der Nervenarzt · 2025Article
- Beyond addiction: exploring the factors behind suicidal thoughts among methamphetamine users in Guangdong, China.BMC public health · 2025Article
- Binge Drug Injection in a Cohort of People Who Inject Drugs in Montreal: Characterizing the Substances and Social Contexts Involved.International journal of mental health and addiction · 2025Article
- Exploring the mechanism of trait depression and cognitive impairment on the formation of among individuals with methamphetamine use disorder under varying degrees of social support.Frontiers in public health · 2025Article
- Article
- Article
- Modeling methamphetamine use disorder in mammals: Sex differences in behavioral, biochemical, and transcriptional consequences.Advances in pharmacology (San Diego, Calif.) · 2024Article
- Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: Potential therapeutic impacts.Neuroscience and biobehavioral reviews · 2022Review
- Co-exposure of cannabinoids with amphetamines and biological, behavioural and health outcomes: a scoping review of animal and human studies.Psychopharmacology · 2022Article
- Opioid use as a proximal risk factor for suicidal behavior in young adults.Suicide & life-threatening behavior · 2022Article
- Development and assessment of a community-based screening tool for mental health disorders among people who inject drugs.Drug and alcohol review · 2022Article
- Article
- 'Resurgent', 'twin' or 'silent' epidemic? A select data overview and observations on increasing psycho-stimulant use and harms in North America.Substance abuse treatment, prevention, and policy · 2021Article
- The role of psychiatric symptoms and environmental vulnerability factors in explaining the relationship between child maltreatment and suicidality: A prospective investigation.Journal of affective disorders · 2020Article
- The role of substance use, smoking, and inflammation in risk for suicidal behavior.Journal of affective disorders · 2019Article
- A psychometric evaluation of the Concise Health Risk Tracking Self-Report (CHRT-SR)- a measure of suicidality-in patients with stimulant use disorder.Journal of psychiatric research · 2018Article
- A Hazard Analysis of Risk Factors of Mortality in Individuals Who Inject Drugs in Denver CO.AIDS and behavior · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMethamphetamine (MA) use is a growing public health concern in many settings around the world. While some physical and mental health effects associated with injection MA use have been well described, little is known about the relationship between injecting MA and suicidal behavior. We sought to determine whether MA injection was associated with an increased risk of attempting suicide among a prospective cohort of injection drug users (IDUs) in Vancouver, Canada.
methodsBetween 2001 and 2008, eligible participants enrolled in the Vancouver Injection Drug Users Study (VIDUS) completed semi-annual questionnaires that elicited information regarding sociodemographics, drug use patterns, and mental health problems including suicidal behavior. We used Cox proportional hazards models with time-dependent covariates to determine whether self-reported MA injection was an independent predictor of attempting suicide at subsequent time points.
resultsOf 1873 eligible participants, 149 (8.0%) reported a suicide attempt, resulting in an incidence density of 2.5 per 100 person-years. Participants who attempted suicide were more likely to be younger (median: 35 vs. 40, p<0.01), female (48.3% vs. 35.1%, p<0.01), and of Aboriginal ancestry (43.6% vs. 31.3%, p<0.01). In a Cox proportional hazards model, MA injection was associated with an 80% increase in the risk of attempting suicide (adjusted hazard ratio=1.80, 95% CI: 1.08-2.99, p=0.02).
conclusionsThese findings suggest that IDUs who inject MA should be monitored for suicidal behavior. Improved integration of mental health and suicide prevention interventions within harm reduction and drug treatment programs may be fruitful.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.