ArticleGenome medicine2011
Factors influencing patient willingness to participate in genetic research after a myocardial infarction.
Article in Genome medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Predictors of consent to pharmacogenomics testing in the IDEAL study.Pharmacogenetics and genomics · 2013Trial
- Randomised trial investigating the relationship of response rate for blood sample donation to site of biospecimen collection, fasting status and reminder letter: the 45 and Up Study.BMC medical research methodology · 2012Trial
- Improving Recruitment Into Research Studies via Electronically Collected Patient-Entered Data: Mixed Methods Study.Journal of medical Internet research · 2025Article
- Participant-reported personal utility of genetic testing for Parkinson's disease and interest in clinical trial participation.NPJ Parkinson's disease · 2024Article
- Factors that influence a patient's decision to engage in genetic research.Frontiers in public health · 2023Article
- Attitudes and experiences regarding genetic research among persons of African descent.Journal of community genetics · 2020Article
- A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.Basic research in cardiology · 2018Observational
- Willingness to Participate in Longitudinal Research Among People with Chronic Pain Who Take Medical Cannabis: A Cross-Sectional Survey.Cannabis and cannabinoid research · 2018Article
- Collecting Biospecimens From an Internet-Based Prospective Cohort Study of Inflammatory Bowel Disease (CCFA Partners): A Feasibility Study.JMIR research protocols · 2016Article
- Article
- Utility of a genetic risk score to predict recurrent cardiovascular events 1 year after an acute coronary syndrome: A pooled analysis of the RISCA, PRAXY, and TRIUMPH cohorts.Atherosclerosis · 2015Article
- Clinical outcomes associated with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups following acute myocardial infarction.The pharmacogenomics journal · 2015Observational
- Genetic research participation in a young adult community sample.Journal of community genetics · 2014Article
- CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014Article
- Cytochrome p450 gene variants, race, and mortality among clopidogrel-treated patients after acute myocardial infarction.Circulation. Cardiovascular genetics · 2014Observational
- Patient characteristics and participation in a genetic study: a type 2 diabetes cohort.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2014Article
- Characteristics associated with informed consent for genetic studies in the ACCORD trial.Contemporary clinical trials · 2014Article
- Characteristics of Australian cohort study participants who do and do not take up an additional invitation to join a long-term biobank: The 45 and Up Study.BMC research notes · 2012Article
- Adrenergic-pathway gene variants influence beta-blocker-related outcomes after acute coronary syndrome in a race-specific manner.Journal of the American College of Cardiology · 2012Article
- Are enrollment sites the key to optimizing participation in genetic studies?Genome medicine · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAchieving 'personalized medicine' requires enrolling representative cohorts into genetic studies, but patient self-selection may introduce bias. We sought to identify characteristics associated with genetic consent in a myocardial infarction (MI) registry.
methodsWe assessed correlates of participation in the genetic sub-study of TRIUMPH, a prospective MI registry (n = 4,340) from 24 US hospitals between April 2005 and December 2008. Factors examined included extensive socio-demographics factors, clinical variables, and study site. Predictors of consent were identified using hierarchical modified Poisson regression, adjusting for study site. Variation in consent rates across hospitals were quantified by the median rate ratio (MRR).
resultsMost subjects consented to donation of their genetic material (n = 3,484; 80%). Participation rates varied greatly between sites, from 40% to 100%. After adjustment for confounding factors, the MRR for hospital was 1.22 (95% confidence interval (CI) 1.11 to 1.29). The only patient-level factors associated with consent were race (RR 0.93 for African Americans versus whites, 95% CI 0.88 to 0.99) and body mass index (RR 1.03 for BMI ≥ 25, 95% CI 1.01 to 1.06).
conclusionAmong patients with an MI there were notable differences in genetic consent by study site, but little association with patient-level factors. This suggests that variation in the way information is presented during recruitment, or other site factors, strongly influence patients' decision to participate in genetic studies.
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