Trial reportCritical care (London, England)2011
Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: a multi-center randomized controlled trial.
Trial report in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00354211 (TREASURE), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TREASURE: Treatment With Minimally-Invasive Cardiac Output for Assessment of User Derived Results Evaluating Economic Benefit
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Association of conflicts of interest with the results and conclusions of goal-directed hemodynamic therapy research: a systematic review with meta-analysis.Intensive care medicine · 2018Pooled it
- Pulmonary artery catheters for adult patients in intensive care.The Cochrane database of systematic reviews · 2013Pooled it
- Continual hemodynamic monitoring with a single-use transesophageal echocardiography probe in critically ill patients with shock: a randomized controlled clinical trial.Intensive care medicine · 2019Trial
- A pragmatic multi-center trial of goal-directed fluid management based on pulse pressure variation monitoring during high-risk surgery.BMC anesthesiology · 2017Trial
- Impact of early haemodynamic goal-directed therapy in patients undergoing emergency surgery: an open prospective, randomised trial.Journal of clinical monitoring and computing · 2016Trial
- Cardiac index assessment using bioreactance in patients undergoing cytoreductive surgery in ovarian carcinoma.Journal of clinical monitoring and computing · 2013Trial
- Goal-directed intraoperative fluid therapy guided by stroke volume and its variation in high-risk surgical patients: a prospective randomized multicentre study.Journal of clinical monitoring and computing · 2013Trial
- Monitoring of perioperative tissue perfusion and impact on patient outcomes.Journal of cardiothoracic surgery · 2025Review
- Expert statement for the management of hypovolemia in sepsis.Intensive care medicine · 2018Review
- Stroke Volume Monitoring: Novel Continuous Wave Doppler Parameters, Algorithms and Advanced Noninvasive Haemodynamic Concepts.Current anesthesiology reports · 2017Review
- Early hemodynamic assessment and treatment of elderly patients in the medical ICU.Wiener klinische Wochenschrift · 2016Article
- Review
- Individualized goal directed perioperative care - the way to go!Frontiers in medicine · 2015Article
- Fluid Therapy: Double-Edged Sword during Critical Care?BioMed research international · 2015Review
- Comparing a non-invasive hemodynamic monitor with minimally invasive monitoring during major open abdominal surgery.Journal of biomedical research · 2014Article
- Clinical review: Goal-directed therapy-what is the evidence in surgical patients? The effect on different risk groups.Critical care (London, England) · 2013Article
- Cardiac parameters in children recovered from acute illness as measured by electrical cardiometry and comparisons to the literature.Journal of clinical monitoring and computing · 2013Article
- Should we use early less invasive hemodynamic monitoring in unstable ICU patients?Critical care (London, England) · 2011Article
- Comparison of cardiac output, IVC diameters and lactate levels in prediction of mortality in patients in emergency department; An observational study.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute hemodynamic instability increases morbidity and mortality. We investigated whether early non-invasive cardiac output monitoring enhances hemodynamic stabilization and improves outcome.
methodsA multicenter, randomized controlled trial was conducted in three European university hospital intensive care units in 2006 and 2007. A total of 388 hemodynamically unstable patients identified during their first six hours in the intensive care unit (ICU) were randomized to receive either non-invasive cardiac output monitoring for 24 hrs (minimally invasive cardiac output/MICO group; n = 201) or usual care (control group; n = 187). The main outcome measure was the proportion of patients achieving hemodynamic stability within six hours of starting the study.
resultsThe number of hemodynamic instability criteria at baseline (MICO group mean 2.0 (SD 1.0), control group 1.8 (1.0); P = .06) and severity of illness (SAPS II score; MICO group 48 (18), control group 48 (15); P = .86)) were similar. At 6 hrs, 45 patients (22%) in the MICO group and 52 patients (28%) in the control group were hemodynamically stable (mean difference 5%; 95% confidence interval of the difference -3 to 14%; P = .24). Hemodynamic support with fluids and vasoactive drugs, and pulmonary artery catheter use (MICO group: 19%, control group: 26%; P = .11) were similar in the two groups. The median length of ICU stay was 2.0 (interquartile range 1.2 to 4.6) days in the MICO group and 2.5 (1.1 to 5.0) days in the control group (P = .38). The hospital mortality was 26% in the MICO group and 21% in the control group (P = .34).
conclusionsMinimally-invasive cardiac output monitoring added to usual care does not facilitate early hemodynamic stabilization in the ICU, nor does it alter the hemodynamic support or outcome. Our results emphasize the need to evaluate technologies used to measure stroke volume and cardiac output--especially their impact on the process of care--before any large-scale outcome studies are attempted.
trial registrationThe study was registered at ClinicalTrials.gov (Clinical Trials identifier NCT00354211).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.