ArticleJournal of biomedical science2011
Carbon monoxide affects electrical and contractile activity of rat myocardium.
Article in Journal of biomedical science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- The role and mechanism of heme oxygenase-1 in arrhythmias.Journal of molecular medicine (Berlin, Germany) · 2024Review
- Characterization of Glutathione Dithiophosphates as Long-Acting HInternational journal of molecular sciences · 2023Article
- Review
- Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure-How Strong Is That Link?Biomolecules · 2022Review
- Carbon monoxide modulates electrical activity of murine myocardium via cGMP-dependent mechanisms.Journal of physiology and biochemistry · 2015Article
- Modulation of sinoatrial node pacemaker activity by carbon monoxide and hydrogen sulfide.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2013Article
- Effects of DL-homocysteine thiolactone on cardiac contractility, coronary flow, and oxidative stress markers in the isolated rat heart: the role of different gasotransmitters.BioMed research international · 2013Article
- Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations.Frontiers in physiology · 2013Article
- Cardiac function dependence on carbon monoxide.Medical gas researchReview
- Air Pollution and Cardiac Diseases: A Review of Experimental Studies.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarbon monoxide (CO) is a toxic gas, which also acts in the organism as a neurotransmitter. It is generated as a by-product of heme breakdown catalyzed by heme oxygenase. We have investigated changes in electrical and contractile activity of isolated rat atrial and ventricular myocardium preparations under the influence of CO.
methodsStandard microelectrode technique was used for intracellular registration of electrical activity in isolated preparations of atrial and ventricular myocardium. Contractions of atrial myocardial stripes were registered via force transducer.
resultsCO (10(-4)-10(-3) M) caused prominent decrease of action potential duration (APD) in working atrial myocardium as well as significant acceleration of sinus rhythm. In addition CO reduced force of contractions and other parameters of contractile activity. Inhibitor of heme oxygenase zinc protoporphyrin IX exerts opposite effects: prolongation of action potential, reduction of sinus rhythm rate and enhancement of contractile function. Therefore, endogenous CO, which may be generated in the heart due to the presence of active heme oxygenase, is likely to exert the same effects as exogenous CO applied to the perfusing medium. In ventricular myocardium preparations exogenous CO also induced shortening of action potential, while zinc protoporphyrin IX produced the opposite effect.
conclusionsThus, endogenous or exogenous carbon monoxide may act as an important regulator of electrical and contractile cardiac activity.
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