ReviewJournal of translational medicine2011
Trauma is danger.
Review in Journal of translational medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- The hidden battlefield: platelet function in the wake of severe trauma.Frontiers in immunology · 2026Review
- Neutrophil Gelatinase-Associated Lipocalin: A Shared Early Biomarker of Remote Organ Dysfunction in Blast-Induced Extremity Trauma.International journal of molecular sciences · 2025Article
- Acute muscle mass loss was alleviated with HMGB1 neutralizing antibody treatment in severe burned rats.Scientific reports · 2023Article
- Alarming Cargo: The Role of Exosomes in Trauma-Induced Inflammation.Biomolecules · 2021Review
- Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study.Molecular medicine (Cambridge, Mass.) · 2021Observational
- Skin Resident γδ T Cell Function and Regulation in Wound Repair.International journal of molecular sciences · 2020Review
- Herpes Virus Entry Mediator (HVEM): A Novel Potential Mediator of Trauma-Induced Immunosuppression.The Journal of surgical research · 2020Article
- Burn and thoracic trauma alters fracture healing, systemic inflammation, and leukocyte kinetics in a rat model of polytrauma.Journal of orthopaedic surgery and research · 2019Article
- Postinjury Inflammation and Organ Dysfunction.Critical care clinics · 2017Review
- Serum levels of HSP70 and other DAMP proteins can aid in patient diagnosis after traumatic injury.Cell stress & chaperones · 2016Article
- Dermal γδ T-Cells Can Be Activated by Mitochondrial Damage-Associated Molecular Patterns.PloS one · 2016Article
- Effects and mechanisms of chinese herbal medicine in ameliorating myocardial ischemia-reperfusion injury.Evidence-based complementary and alternative medicine : eCAM · 2013Review
- Regulation of innate immunity by extracellular nucleotides.American journal of blood research · 2013Article
- Danger signals activating the immune response after trauma.Mediators of inflammation · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTrauma is one of the leading causes of death in young adult patients. Many pre-clinical and clinical studies attempt to investigate the immunological pathways involved, however the true mediators remain to be elucidated. Herein, we attempt to describe the immunologic response to systemic trauma in the context of the Danger model. DATA SOURCES: A literature search using PubMed was used to identify pertinent articles describing the Danger model in relation to trauma.
conclusionsOur knowledge of Danger signals in relation to traumatic injury is still limited. Danger/alarmin signals are the most proximal molecules in the immune response that have many possibilities for effector function in the innate and acquired immune systems. Having a full understanding of these molecules and their pathways would give us the ability to intervene at such an early stage and may prove to be more effective in blunting the post-injury inflammatory response unlike previously failed cytokine experiments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.