ArticleBipolar disorders2011
A functional MRI study of working memory in adolescents and young adults at genetic risk for bipolar disorder: preliminary findings.
Article in Bipolar disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- The impact of affective information on working memory: A pair of meta-analytic reviews of behavioral and neuroimaging evidence.Psychological bulletin · 2019Pooled it
- Fractal Analysis of Brain Activity During Risky Drinking in Adolescents and Young Adults.Brain sciences · 2025Article
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- Deficits in sustained attention in adolescents with bipolar disorder during their first manic episode.Journal of affective disorders · 2023Article
- The Association Between Insular Subdivisions Functional Connectivity and Suicide Attempt in Adolescents and Young Adults with Major Depressive Disorder.Brain topography · 2021Article
- Impairments of working memory in schizophrenia and bipolar disorder: the effect of history of psychotic symptoms and different aspects of cognitive task demands.Frontiers in behavioral neuroscience · 2014Article
- Meta-analyses of developing brain function in high-risk and emerged bipolar disorder.Frontiers in psychiatry · 2014Article
- Working memory network alterations and associated symptoms in adults with ADHD and Bipolar Disorder.Journal of psychiatric research · 2012Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
objectivesIn this report, we seek to (i) identify a potential neuroimaging endophenotype for bipolar disorder (BD) in emotion regulatory and autonomic circuitry in young first-degree relatives of persons with BD; and (ii) replicate our previous work identifying the functional neuroanatomy of working memory (WM) in an older sample of relatives of persons with BD.
methodsTen adolescent and young adult (age 13-24) unmedicated, non-ill, first-degree relatives of persons with BD (RELS) and 10 demographically comparable healthy controls performed a 2-back WM task and a 0-back control task during functional magnetic resonance imaging (fMRI). fMRI data were collected on a 1.5 Tesla scanner and analyzed using SPM-2. Mood was assessed on the day of scanning.
resultsThe groups did not differ on any demographic, neuropsychological, or in-scanner task performance variables. In contrast to controls, RELS showed (i) weak task-dependent modulation activity in the cerebellar vermis (CV), insula, and amygdala/parahippocampal region, and (ii) exaggerated modulation of activity in the frontopolar cortex and brainstem, even after controlling for potential confounders. Many of the group differences were driven by differences in activity in the low-level (0-back) baseline task.
conclusionsYoung, unmedicated RELS exhibited altered task-dependent modulation of frontopolar, CV, and insula activity during WM, especially during the low-level (0-back) baseline task. Results are largely consistent with our initial study of older adult RELS, suggesting these alterations may represent biomarkers of genetic risk for BD.
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