Trial reportAlcoholism, clinical and experimental research2011
Neural and behavioral mechanisms of impulsive choice in alcohol use disorder.
Trial report in Alcoholism, clinical and experimental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03842670 (Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological), which is not on this map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological
Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review of Obesity and Binge Eating Associated Impairment of the Cognitive Inhibition System.Frontiers in nutrition · 2021Pooled it
- Steep delay discounting and addictive behavior: a meta-analysis of continuous associations.Addiction (Abingdon, England) · 2017Pooled it
- Exercise and diet effects on delay discounting and related neurobiology in adults with overweight or obesity: A randomized trial.Obesity (Silver Spring, Md.) · 2025Trial
- Brain regions affected by impaired control modulate responses to alcohol and smoking cues.Journal of studies on alcohol and drugs · 2014Trial
- Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics.Psychopharmacology · 2013Trial
- Neuroeconomics and myopia prevention: A framework for public health intervention.Acta ophthalmologica · 2026Review
- Diagnostic validity of alcohol demand and monetary delay discounting in relation to alcohol use disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2025Article
- Disrupted decision making in adult male rats after prolonged withdrawal from ethanol vapor exposure.Alcohol, clinical & experimental research · 2025Article
- The effect of stress on delay discounting in female patients with early-onset bulimia nervosa and alcohol use disorder: functional magnetic resonance imaging study.BJPsych open · 2025Article
- Chronic alcohol exposure alters action control via hyperactive premotor corticostriatal activity.Cell reports · 2023Article
- Risky Decision-Making in Adults with Alcohol Use Disorder-A Systematic and Meta-Analytic Review.Journal of clinical medicine · 2023Review
- Family history of substance use disorder and parental impulsivity are differentially associated with neural responses during risky decision-making.Frontiers in neuroimaging · 2023Article
- Neuroeconomic predictors of smoking cessation outcomes: A preliminary study of delay discounting in treatment-seeking adult smokers.Psychiatry research. Neuroimaging · 2022Article
- Delay discounting and alcohol consumption correlate with dorsal anterior insula activation during choice in nontreatment-seeking heavy drinkers.Alcoholism, clinical and experimental research · 2022Article
- The Resting-State Neural Network of Delay Discounting.Frontiers in psychology · 2022Article
- Targeting the Salience Network: A Mini-Review on a Novel Neuromodulation Approach for Treating Alcohol Use Disorder.Frontiers in psychiatry · 2022Review
- Brain structure and problematic alcohol use: a test of plausible causation using latent causal variable analysis.Brain imaging and behavior · 2021Article
- Binge ethanol drinking associated with sex-dependent plasticity of neurons in the insula that project to the bed nucleus of the stria terminalis.Neuropharmacology · 2021Article
- Disentangling substance use and related problems: urgency predicts substance-related problems beyond the degree of use.BMC psychiatry · 2021Article
- Brain Network Underlying Executive Functions in Gambling and Alcohol Use Disorders: An Activation Likelihood Estimation Meta-Analysis of fMRI Studies.Brain sciences · 2020Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundAlcohol dependence has repeatedly been associated with impulsive choice, or the inability to choose large delayed rewards over smaller, but more immediate rewards. However, the neural basis of impulsive choice in alcohol use disorders (AUDs) is not well understood.
methodsOne hundred fifty-one individuals with a range of alcohol use from social drinking to severe alcohol dependence completed a delay discounting task while undergoing functional magnetic resonance imaging. Participants received customized trials designed to ensure an approximately equivalent number of immediate responses.
resultsDelaying gratification recruited regions involved in cognitive control, conflict monitoring, and the interpretation of somatic states. Individuals with more severe alcohol use problems showed increased discounting of delayed rewards and greater activation in several regions including supplementary motor area, insula/orbitofrontal cortex, inferior frontal gyrus, and the precuneus.
conclusionsThese results suggest that impulsive choice in alcohol dependence is the result of functional anomalies in widely distributed, but interconnected brain regions involved in cognitive and emotional control. Furthermore, our results suggest that the neural mechanisms of impulsive choice in AUD both overlaps with that observed in previous studies, and shows that individuals with AUD recruit additional mechanisms when making intertemporal choices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.