ArticleInternational journal of radiation biology2011
Mitigation of radiation-induced lung injury by genistein and EUK-207.
Article in International journal of radiation biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 77 citations in OpenAlex.
- Contribution of immune cells and cytokines to radiation-induced injury: the key roles and potential targets.Frontiers in immunology · 2026Review
- Advances in noninvasive imaging for detecting radiation-induced lung injury (RILI).International journal of radiation biology · 2025Review
- Immuno-protective impact and clinical translation of radioprotective agents in cancer radiotherapy.Frontiers in immunology · 2025Review
- Impact of dietary ingredients on radioprotection and radiosensitization: a comprehensive review.Annals of medicine · 2024Review
- Balanced Duality: HInternational journal of molecular sciences · 2024Review
- Irradiation and Alterations in Hippocampal DNA Methylation.Epigenomes · 2024Review
- Review
- The role of isoflavones in augmenting the effects of radiotherapy.Frontiers in oncology · 2022Review
- Dietary Phytoestrogens Ameliorate Hydrochloric Acid-Induced Chronic Lung Injury and Pulmonary Fibrosis in Mice.Nutrients · 2021Article
- Grape Seed Proanthocyanidins play the roles of radioprotection on Normal Lung and radiosensitization on Lung Cancer via differential regulation of the MAPK Signaling Pathway.Journal of Cancer · 2021Article
- Pursuing the Elixir of Life: In Vivo Antioxidative Effects of Manganosalen Complexes.Antioxidants (Basel, Switzerland) · 2020Review
- Mitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2020Article
- Attenuation of Radiation-Induced Lung Injury by Hyaluronic Acid Nanoparticles.Frontiers in pharmacology · 2020Article
- Mitigation of Radiation-Induced Lung Pneumonitis and Fibrosis Using Metformin and Melatonin: A Histopathological Study.Medicina (Kaunas, Lithuania) · 2019Article
- Expanding the therapeutic index of radiation therapy by normal tissue protection.The British journal of radiology · 2019Review
- Pharmacology of natural radioprotectors.Archives of pharmacal research · 2018Review
- BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high-dose radiation exposure in the C57L/J murine model.British journal of pharmacology · 2017Article
- Mechanisms of Normal Tissue Injury From Irradiation.Seminars in radiation oncology · 2017Review
- Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades.Radiation oncology (London, England) · 2017Review
- Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression.Antioxidants & redox signaling · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeWe examined the effects of genistein and/or Eukarion (EUK)-207 on radiation-induced lung damage and investigated whether treatment for 0-14 weeks (wks) post-irradiation (PI) would mitigate late lung injury. MATERIALS AND
methodsThe lungs of female Sprague-Dawley (SD) rats were irradiated with 10 Gy. EUK-207 was delivered by infusion and genistein was delivered as a dietary supplement starting immediately after irradiation (post irradiation [PI]) and continuing until 14 wks PI. Rats were sacrificed at 0, 4, 8, 14 and 28 wks PI. Breathing rate was monitored and lung fibrosis assessed by lung hydroxyproline content at 28 wks. DNA damage was assessed by micronucleus (MN) assay and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels. The expression of the cytokines Interleukin (IL)-1α, IL-1β, IL-6, Tumor necrosis factor (TNF)-α and Transforming growth factor (TGF)-β1, and macrophage activation were analyzed by immunohistochemistry.
resultsIncreases in breathing rate observed in the irradiated rats were significantly reduced by both drug treatments during the pneumonitis phase and the later fibrosis phase. The drug treatments decreased micronuclei (MN) formation from 4-14 wks but by 28 wks the MN levels had increased again. The 8-OHdG levels were lower in the drug treated animals at all time points. Hydroxyproline content and levels of activated macrophages were decreased at 28 wks in all drug treated rats. The treatments had limited effects on the expression of the cytokines.
conclusionGenistein and EUK-207 can provide partial mitigation of radiation-induced lung damage out to at least 28 wks PI even after cessation of treatment at 14 wks PI.
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Registered trials
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