ArticleInflammatory bowel diseases2011
Maternal obesity induces sustained inflammation in both fetal and offspring large intestine of sheep.
Article in Inflammatory bowel diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 76 citations in OpenAlex.
- Maternal metabolic stress regulates progeny intestinal stem cell niche signaling through heritable changes in redox metabolites.Nature communications · 2026Article
- The fetal exposome: cellular and epigenetic programming of neonatal immune function.Frontiers in immunology · 2026Review
- Developmental origins of immunometabolic health.Immunometabolism (Cobham, Surrey) · 2026Review
- Interactions among factors affecting stillbirths in Egyptian buffaloes (Bubalus bubalis).Tropical animal health and production · 2025Article
- Effects of maternal overnutrition and metabolic challenge in adult life on the histological integrity of the liver and intestinal epithelium in rabbits.Frontiers in nutrition · 2025Article
- Analysis of Protection and Immune Response againstVaccines · 2024Article
- The effect of chronic, non-pathogenic maternal immune activation on offspring postnatal muscle and immune outcomes.Journal of animal science · 2024Article
- Maternal high-fat diet increases the susceptibility of offspring to colorectal cancer via the activation of intestinal inflammation.Frontiers in nutrition · 2023Review
- Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Impact of Obesity on the Course of Management of Inflammatory Bowel Disease-A Review.Nutrients · 2022Review
- Butyrate supplementation to pregnant mice elicits cytoprotection against colonic injury in the offspring.Pediatric research · 2022Article
- Dietary rumen-protected L-arginine orAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Adiposity, reproductive and metabolic health, and activity levels in zoo Asian elephant (The Journal of experimental biology · 2021Article
- Excess calorie intake early in life increases susceptibility to colitis in adulthood.Nature metabolism · 2019Article
- Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming.Journal of leukocyte biology · 2019Review
- Real supermodels wear wool: summarizing the impact of the pregnant sheep as an animal model for adaptive fetal programming.Animal frontiers : the review magazine of animal agriculture · 2019Article
- Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury.Frontiers in endocrinology · 2019Review
- Environmental triggers in IBD: a review of progress and evidence.Nature reviews. Gastroenterology & hepatology · 2018Review
- Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases.Journal of clinical medicine · 2017Review
- Maternal high-fat diet consumption enhances offspring susceptibility to DSS-induced colitis in mice.Obesity (Silver Spring, Md.) · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBoth maternal obesity and inflammatory bowel diseases (IBDs) are increasing. It was hypothesized that maternal obesity induces an inflammatory response in the fetal large intestine, predisposing offspring to IBDs.
methodsNonpregnant ewes were assigned to a control (Con, 100% of National Research Council [NRC] recommendations) or obesogenic (OB, 150% of NRC) diet from 60 days before conception. The large intestine was sampled from fetuses at 135 days (term 150 days) after conception and from offspring lambs at 22.5 ± 0.5 months of age.
resultsMaternal obesity enhanced mRNA expression tumor necrosis factor (TNF)α, interleukin (IL)1α, IL1β, IL6, IL8, and monocyte/macrophage chemotactic protein-1 (MCP1), as well as macrophage markers, CD11b, CD14, and CD68 in fetal gut. mRNA expression of Toll-like receptor (TLR) 2 and TLR4 was increased in OB versus Con fetuses; correspondingly, inflammatory NF-κB and JNK signaling pathways were also upregulated. Both mRNA expression and protein content of transforming growth factor (TGF) β was increased. The IL-17A mRNA expression and protein content was higher in OB compared to Con samples, which was associated with fibrosis in the large intestine of OB fetuses. Similar inflammatory responses and enhanced fibrosis were detected in OB compared to Con offspring.
conclusionsMaternal obesity induced inflammation and enhanced expression of proinflammatory cytokines in fetal and offspring large intestine, which correlated with increased TGFβ and IL17 expression. These data show that maternal obesity may predispose offspring gut to IBDs.
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