ArticleHuman brain mapping2012
Neurodegeneration in friedreich's ataxia is associated with a mixed activation pattern of the brain. A fMRI study.
Article in Human brain mapping, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Functional MRI Studies in Friedreich's Ataxia: A Systematic Review.Frontiers in neurology · 2021Pooled it
- Impaired cognitive flexibility and disrupted cognitive cerebellum in degenerative cerebellar ataxias.Brain communications · 2024Article
- Reduced cerebello-cerebral functional connectivity correlates with disease severity and impaired white matter integrity in Friedreich ataxia.Journal of neurology · 2023Article
- Proprioceptive and tactile processing in individuals with Friedreich ataxia: an fMRI study.Frontiers in neurology · 2023Article
- Longitudinal investigation of brain activation during motor tasks in Friedreich ataxia: 24-month data from IMAGE-FRDA.Brain structure & function · 2022Article
- Hand Dexterity and Pyramidal Dysfunction in Friedreich Ataxia, A Finger Tapping Study.Movement disorders clinical practice · 2021Article
- Pattern of Cerebellar Atrophy in Friedreich's Ataxia-Using the SUIT Template.Cerebellum (London, England) · 2019Article
- Cognitive and functional connectivity alterations in Friedreich's ataxia.Annals of clinical and translational neurology · 2018Article
- Fast and Accurate Detection of Complex Imaging Genetics Associations Based on Greedy Projected Distance Correlation.IEEE transactions on medical imaging · 2018Article
- Functional and Structural Brain Damage in Friedreich's Ataxia.Frontiers in neurology · 2018Article
- Measuring Inhibition and Cognitive Flexibility in Friedreich Ataxia.Cerebellum (London, England) · 2017Article
- Cerebral and cerebellar grey matter atrophy in Friedreich ataxia: the IMAGE-FRDA study.Journal of neurology · 2016Article
- Cognition in Friedreich's ataxia: a behavioral and multimodal imaging study.Annals of clinical and translational neurology · 2016Article
- Fronto-cerebellar dysfunction and dysconnectivity underlying cognition in friedreich ataxia: The IMAGE-FRDA study.Human brain mapping · 2016Article
- Structural and functional MRI abnormalities of cerebellar cortex and nuclei in SCA3, SCA6 and Friedreich's ataxia.Brain : a journal of neurology · 2015Article
- Article
- Cognitive deficits in Friedreich ataxia correlate with micro-structural changes in dentatorubral tract.Cerebellum (London, England) · 2014Article
- The burden of microstructural damage modulates cortical activation in elderly subjects with MCI and leuko-araiosis. A DTI and fMRI study.Human brain mapping · 2014Article
- Excessive motor overflow reveals abnormal inter-hemispheric connectivity in Friedreich ataxia.Journal of neurology · 2013Article
- Hypoactivation of the primary sensorimotor cortex in de novo Parkinson's disease : a motor fMRI study under controlled conditions.Neuroradiology · 2012Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Friedreich's ataxia (FRDA) is associated with a distributed pattern of neurodegeneration in the spinal cord and the brain secondary to selective neuronal loss. We used functional MR Imaging (fMRI) to explore brain activation in FRDA patients during two motor-sensory tasks of different complexity, i.e. continuous hand tapping and writing of "8" figure, with the right dominant hand and without visual feedback. Seventeen FRDA patients and two groups of age-matched healthy controls were recruited. Task execution was monitored and recorded using MR-compatible devices. Hand tapping was correctly performed by 11 (65%) patients and writing of the "8" by 7 (41%) patients. After correction for behavioral variables, FRDA patients showed in both tasks areas of significantly lower activation in the left primary sensory-motor cortex and right cerebellum. Also left thalamus and right dorsolateral prefrontal cortex showed hypo-activation during hand tapping. During writing of the "8" task FRDA patients showed areas of higher activation in the right parietal and precentral cortex, globus pallidus, and putamen. Activation of right parietal cortex, anterior cingulum, globus pallidus, and putamen during writing of the "8" increased with severity of the neurological deficit. In conclusion fMRI demonstrates in FRDA a mixed pattern constituted by areas of decreased activation and areas of increased activation. The decreased activation in the primary motor cortex and cerebellum presumably reflects a regional neuronal damage, the decreased activation of the left thalamus and primary sensory cortex could be secondary to deafferentation phenomena, and the increased activation of right parietal cortex and striatum might have a possible compensatory significance.
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