ArticleNMR in biomedicine2011
Assessment of multiparametric MRI in a human glioma model to monitor cytotoxic and anti-angiogenic drug effects.
Article in NMR in biomedicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Glioblastoma multiforme restructures the topological connectivity of cerebrovascular networks.Scientific reports · 2019Article
- Characterization of the serum metabolome following radiation treatment in patients with high-grade gliomas.Radiation oncology (London, England) · 2016Article
- Article
- Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2.Scientific reports · 2015Article
- Current standards and new concepts in MRI and PET response assessment of antiangiogenic therapies in high-grade glioma patients.Neuro-oncology · 2015Review
- Functional MRI and CT biomarkers in oncology.European journal of nuclear medicine and molecular imaging · 2015Review
- Vessel caliber--a potential MRI biomarker of tumour response in clinical trials.Nature reviews. Clinical oncology · 2014Review
- Tissue oxygen saturation mapping with magnetic resonance imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- Microvascular MRI and unsupervised clustering yields histology-resembling images in two rat models of glioma.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- Characterization of the 9L gliosarcoma implanted in the Fischer rat: an orthotopic model for a grade IV brain tumor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- MRI biomarkers identify the differential response of glioblastoma multiforme to anti-angiogenic therapy.Neuro-oncology · 2014Article
- Assessing the reproducibility of dynamic contrast enhanced magnetic resonance imaging in a murine model of breast cancer.Magnetic resonance in medicine · 2013Article
- Diffusion-Weighted MRI as a Biomarker of Tumor Radiation Treatment Response Heterogeneity: A Comparative Study of Whole-Volume Histogram Analysis versus Voxel-Based Functional Diffusion Map Analysis.Translational oncology · 2013Article
- A simulation tool for dynamic contrast enhanced MRI.PloS one · 2013Article
- Article
- MRI measurements of vessel calibre in tumour xenografts: comparison with vascular corrosion casting.Microvascular research · 2012Article
- Practical dynamic contrast enhanced MRI in small animal models of cancer: data acquisition, data analysis, and interpretation.Pharmaceutics · 2012Article
- Distribution and radiosensitizing effect of cholesterol-coupled Dbait molecule in rat model of glioblastoma.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early imaging or blood biomarkers of tumor response is needed to customize anti-tumor therapy on an individual basis. This study evaluates the sensitivity and relevance of five potential MRI biomarkers. Sixty nude rats were implanted with human glioma cells (U-87 MG) and randomized into three groups: one group received an anti-angiogenic treatment (Sorafenib), a second a cytotoxic drug [1,3-bis(2-chloroethyl)-1-nitrosourea, BCNU (Carmustine)] and a third no treatment. The tumor volume, apparent diffusion coefficient (ADC) of water, blood volume fraction (BVf), microvessel diameter (vessel size index, VSI) and vessel wall integrity (contrast enhancement, CE) were monitored before and during treatment. Sorafenib reduced tumor CE as early as 1 day after treatment onset. By 4 days after treatment onset, tumor BVf was reduced and tumor VSI was increased. By 14 days after treatment onset, ADC was increased and the tumor growth rate was reduced. With BCNU, ADC was increased and the tumor growth rate was reduced 14 days after treatment onset. Thus, the estimated MRI parameters were sensitive to treatment at different times after treatment onset and in a treatment-dependent manner. This study suggests that multiparametric MR monitoring could allow the assessment of new anti-tumor drugs and the optimization of combined therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.