ReviewNeurochemical research1990
Endothelin: a review of its effects and possible mechanisms of action.
Review in Neurochemical research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 50 citations in OpenAlex.
- The interdependence of endothelin-1 and calcium: a review.Clinical science (London, England : 1979) · 2010Review
- Differential regulation of two types of intracellular calcium release channels during end-stage heart failure.The Journal of clinical investigation · 1995Article
- Vascular mechanisms of cyclosporin-induced hypertension in the rat.The Journal of clinical investigation · 1994Article
- Inositol 1,4,5-trisphosphate receptor expression in cardiac myocytes.The Journal of cell biology · 1993Article
- Endothelium-dependent mesenteric vasorelaxant effects and systemic actions of endothelin (16-21) and other endothelin-related peptides in the rat.British journal of pharmacology · 1991Article
- Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Endothelin signaling pathways in rat adrenal medulla.Cellular and molecular neurobiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recently identified endothelium-derived peptide, endothelin, is a potent vasoconstrictor, but also binds specifically to many types of smooth muscle and to nerve tissue. Endothelin has been detected in plasma and may have physiological or pathological functions. Like other agonists, endothelin increases the turnover of phosphatidyl inositol and liberates intracellular stocks of Ca2+. It also increases plasmalemmal Ca2+ permeability, an effect that is antagonized by calcium entry blockers in some tissues. However, the characteristics of this antagonism are not always typical of that seen when other types of agonists are employed. It seems that in at least some cell types endothelin might activate specific L-type Ca2+ channels indirectly, perhaps secondarily to the activation of another type of cation channel. The endothelin originally described is one of a family of peptides that are closely related to the sarafotoxins. The comparative pharmacology of these peptides and of some analogues of the originally described endothelin have revealed some surprising differences and may indicate the existence of different endothelin receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.