ArticleThe Journal of comparative neurology2012
Stability of presynaptic vesicle pools and changes in synapse morphology in the amygdala following fear learning in adult rats.
Article in The Journal of comparative neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Aberrant Fear: Biological Underpinnings Relevant to Psychosis, Antipsychotic Drugs, and Psychotherapeutic Treatments, a Translational Approach.International journal of molecular sciences · 2026Review
- Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets.Molecular biomedicine · 2025Review
- Metabolic and Inflammatory Stimuli Impact Vascular Circulation and Cell Proliferation Processes in the Amygdala.Genes, brain, and behavior · 2025Article
- Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- Persistent up-regulation of polyribosomes at synapses during long-term memory, reconsolidation, and extinction of associative memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Local mRNA translation and cytoskeletal reorganization: Mechanisms that tune neuronal responses.Frontiers in molecular neuroscience · 2022Review
- Neural correlates of safety learning.Behavioural brain research · 2021Article
- A Picture Worth a Thousand Molecules-Integrative Technologies for Mapping Subcellular Molecular Organization and Plasticity in Developing Circuits.Frontiers in synaptic neuroscience · 2020Article
- Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala.eLife · 2019Article
- Closing the gap: long-term presynaptic plasticity in brain function and disease.Current opinion in neurobiology · 2017Review
- Article
- Linking Mitochondria to Synapses: New Insights for Stress-Related Neuropsychiatric Disorders.Neural plasticity · 2016Review
- Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A resource from 3D electron microscopy of hippocampal neuropil for user training and tool development.Scientific data · 2015Article
- Synapses lacking astrocyte appear in the amygdala during consolidation of Pavlovian threat conditioning.The Journal of comparative neurology · 2014Article
- Developmental patterns of sleep slow wave activity and synaptic density in adolescent mice.Sleep · 2014Article
- Indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 mice.Frontiers in behavioral neuroscience · 2013Article
- Reactivating fear memory under propranolol resets pre-trauma levels of dendritic spines in basolateral amygdala but not dorsal hippocampus neurons.Frontiers in behavioral neuroscience · 2013Article
- Inhibition of fear by learned safety signals: a mini-symposium review.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Review
- Nanoscale analysis of structural synaptic plasticity.Current opinion in neurobiology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Changes in synaptic strength in the lateral amygdala (LA) that occur with fear learning are believed to mediate memory storage, and both presynaptic and postsynaptic mechanisms have been proposed to contribute. In a previous study we used serial section transmission electron microscopy (ssTEM) to observe differences in dendritic spine morphology in the adult rat LA after fear conditioning, conditioned inhibition (safety conditioning), or naïve control handling (Ostroff et al. [2010] Proc Natl Acad Sci U S A 107:9418-9423). We have now reconstructed axons from the same dataset and compared their morphology and relationship to the postsynaptic spines between the three training groups. Relative to the naïve control and conditioned inhibition groups, the ratio of postsynaptic density (PSD) area to docked vesicles at synapses was greater in the fear-conditioned group, while the size of the synaptic vesicle pools was unchanged. There was significant coherence in synapse size between neighboring boutons on the same axon in the naïve control and conditioned inhibition groups, but not in the fear-conditioned group. Within multiple-synapse boutons, both synapse size and the PSD-to-docked vesicle ratio were variable between individual synapses. Our results confirm that synaptic connectivity increases in the LA with fear conditioning. In addition, we provide evidence that boutons along the same axon and even synapses on the same bouton are independent in their structure and learning-related morphological plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.