Evidence map›Paper›PMID 21674222›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2011

Cancer-associated retinopathy presenting as retinal vasculitis with a negative ERG suggestive of on-bipolar cell pathway dysfunction.

Anastasios Anastasakis, Andrew D Dick, Erika M Damato, Paul G Spry, Mohamed A Majid

Abstract readCase Reports
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In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. American journal of ophthalmology case reports · 2024
    Article
  4. Article
  5. Electroretinographic findings in retinal vasculitis.The British journal of ophthalmology · 2023
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  17. Retinal Vasculitis Secondary to Durvalumab.Case reports in ophthalmology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anastasios AnastasakisBristol Eye Hospital, Lower Maudlin Street, UK. tasosanastasakis@gmail.com
Andrew D Dick
Erika M Damato
Paul G Spry
Mohamed A Majid

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 62-year-old female patient presented to our clinic complaining of a 2 month history of shimmering photopsias and floaters. An ocular examination, fluorescein angiography, and electrophysiological testing were obtained that suggested either an inflammatory retinal vasculitis or a paraneoplastic syndrome. Melanoma-associated retinopathy was highly suspected despite the absence of previous history for cutaneous melanoma since an electronegative scotopic ERG was recorded on standard flash electroretinography. Additional investigations revealed the presence of a primary breast tumor with secondary lung and pancreatic metastasis that led to the diagnosis of cancer-associated retinopathy. The patient received chemotherapy and 4 months after the initial presentation her visual complaints but also her retinal function showed marked improvement. Cancer-associated retinopathy needs to be considered in patients presenting with retinal vasculitis and electrophysiological testing can tailor the approach in these cases.

Indexed as

ElectroretinographyAntineoplastic AgentsBiopsyBreast NeoplasmsCarcinoma, LobularFemaleFluorescein AngiographyHumansLung NeoplasmsMiddle AgedPancreatic NeoplasmsParaneoplastic SyndromesRetinal Bipolar CellsRetinal VasculitisTomography, X-Ray ComputedVisual AcuityAntineoplastic Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.