SynthesisJournal of bone and mineral metabolism2012
Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials.
Synthesis in Journal of bone and mineral metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Association between dietary fiber intake and bone mineral density: a systematic review and meta-analysis of observational studies.European journal of nutrition · 2026Pooled it
- Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2022Pooled it
- The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials.Journal of orthopaedic surgery and research · 2021Pooled it
- The efficacy and safety of menatetrenone in the management of osteoporosis: a systematic review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Pooled it
- Vitamin K intake and the risk of fractures: A meta-analysis.Medicine · 2017Pooled it
- Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Pooled it
- Comparison of concurrent treatment with vitamin KJournal of bone and mineral metabolism · 2017Trial
- Design of a randomized clinical trial of concurrent treatment with vitamin K2 and risedronate compared to risedronate alone in osteoporotic patients: Japanese Osteoporosis Intervention Trial-03 (JOINT-03).Journal of bone and mineral metabolism · 2014Trial
- Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.Journal of bone and mineral metabolism · 2014Trial
- Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Trial
- Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study.European journal of nutrition · 2013Trial
- Serum level of under-carboxylated osteocalcin and bone mineral density in early menopausal Norwegian women.European journal of nutrition · 2013Trial
- Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women.Nutrition journal · 2012Trial
- Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice.Bone research · 2026Article
- Vitamin K2 in Health and Disease: A Clinical Perspective.Foods (Basel, Switzerland) · 2024Review
- Vitamin K intake levels are associated with bone health in people aged over 50 years: a NHANES-based survey.Frontiers in medicine · 2024Article
- Review
- The mediation effect of vitamin A and vitamin D supplement in the association between serum vitamin K levels and musculoskeletal disorders in preschool children.Frontiers in nutrition · 2023Article
- Vitamin K - sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity.Nutrition reviews · 2022Review
- Issues related to the research on vitamin K supplementation and bone mineral density.European journal of clinical nutrition · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of randomized controlled trials (RCTs) examining the role of vitamin K on bone mineral density (BMD) have yielded inconsistent results. We performed a meta-analysis of these trials to assess the effect of vitamin K on BMD. We searched MEDLINE, EMBASE and CENTRAL for relevant studies of RCTs examining the role of vitamin K on BMD. Data on participants, interventions, and outcomes were extracted and the quality of all included trials assessed. Primary outcomes for analysis were absolute changes in BMD (mg/cm(2)) at the lumbar spine and femoral neck. Relative changes (percentage change) in BMD at the lumbar spine were also assessed. Vitamin K supplementation was shown to be efficacious in increasing BMD at the lumbar spine but not the femoral neck. The weighted mean difference (WMD) in BMD absolute change was 21.60 mg/cm(2) [95% confidence interval (CI) 3.63, 39.56] at the lumbar spine and 0.25 mg/cm(2) (95% CI -2.64, 3.14) at the femoral neck. The WMD in BMD relative change was 1.27% (95% CI 0.47, 2.06) at the lumbar spine and 0.17 (95% CI -0.21, 0.54) at the femoral neck. Subgroup analysis revealed that ethnic difference, gender, and vitamin K type were associated with variable effects on BMD at the lumbar spine. The modest overall treatment effects for vitamin K on BMD observed in this review may be biased and should be interpreted with caution. Further studies are required to address factors relating to the observed effects of vitamin K on BMD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.