Evidence map›Paper›PMID 21674197›Full record

ReviewJournal of neurology2011

From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: recent advances in our understanding of disorders of consciousness.

Marie-Aurélie Bruno, Audrey Vanhaudenhuyse, Aurore Thibaut, Gustave Moonen, Steven Laureys

4 registry-linked trialsOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 276 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
276citing papers in PubMed, 7 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02644265 unknown statusnot on this mapstarted 2017, after this paper: background citation

CONNECT-ME: CONsciousness in NEurocritical Care cohorT Study Using fMRI and EEG

Typeobservational_patient_registrySponsorRigshospitalet, DenmarkRan2017 to 2025Enrolled100ConditionsAcute Brain Injuries, Consciousness Disorders
NCT05819177 completednot on this map

An Analysis of the Information of the Coma Recovery Scale-Revised Providing the Most Reliable Prediction of the Neurobehavioral State and Recovery of Consciousness

TypeobservationalSponsorHospitales NisaRan2004 to 2021Enrolled171ConditionsDisorder of ConsciousnessArmsRehabilitation program
NCT05954650 completednot on this map

Minimally Conscious State Plus Versus Minus: Likelihood of Emergence and Long-term Functional Independence

TypeobservationalSponsorHospitales NisaRan2004 to 2023Enrolled80ConditionsDisorder of ConsciousnessArmsRehabilitation
NCT06268236 narecruitingnot on this mapstarted 2024, after this paper: background citation

Electro-acupuncture to Treat Disorder of Consciousness

TypeinterventionalSponsorThe Second Affiliated Hospital, Guangzhou University of Traditional Chinese MedicineRan2024 to 2026Enrolled50ConditionsDisorder of Consciousness, ElectroacupunctureArmsElectroacupuncture, Sham electroacupuncture
3 · Its place in the literature

Who cites it

276 citing papers in PubMed, 7 syntheses or guidelines pooled it, 671 citations in OpenAlex.

  1. Predicting outcome in disorders of consciousness: A mega-analysis.Annals of clinical and translational neurology · 2024
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  4. What names for covert awareness? A systematic review.Frontiers in human neuroscience · 2022
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  20. Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
    Review

216 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marie-Aurélie BrunoComa Science Group, Neurology Department and Cyclotron Research Centre, University Hospital and University of Liège, Liège, Belgium.
Audrey Vanhaudenhuyse
Aurore Thibaut
Gustave Moonen
Steven Laureys
University of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional neuroimaging and electrophysiology studies are changing our understanding of patients with coma and related states. Some severely brain damaged patients may show residual cortical processing in the absence of behavioural signs of consciousness. Given these new findings, the diagnostic errors and their potential effects on treatment as well as concerns regarding the negative associations intrinsic to the term vegetative state, the European Task Force on Disorders of Consciousness has recently proposed the more neutral and descriptive term unresponsive wakefulness syndrome. When vegetative/unresponsive patients show minimal signs of consciousness but are unable to reliably communicate the term minimally responsive or minimally conscious state (MCS) is used. MCS was recently subcategorized based on the complexity of patients' behaviours: MCS+ describes high-level behavioural responses (i.e., command following, intelligible verbalizations or non-functional communication) and MCS- describes low-level behavioural responses (i.e., visual pursuit, localization of noxious stimulation or contingent behaviour such as appropriate smiling or crying to emotional stimuli). Finally, patients who show non-behavioural evidence of consciousness or communication only measurable via para-clinical testing (i.e., functional MRI, positron emission tomography, EEG or evoked potentials) can be considered to be in a functional locked-in syndrome. An improved assessment of brain function in coma and related states is not only changing nosology and medical care but also offers a better-documented diagnosis and prognosis and helps to further identify the neural correlates of human consciousness.

Indexed as

WakefulnessConsciousnessHumansPersistent Vegetative StateQuadriplegia

Identifiers

PMID21674197
OpenAlexW2106243645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.