ArticleMolecular biology reports2012
The protective effect of quercetin on long-term alcohol consumption-induced oxidative stress.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- The protective effect of quercetin in the alcohol-induced liver and lymphoid tissue injuries in newborns.Molecular biology reports · 2020Article
- Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview.BioMed research international · 2019Review
- Spectroscopic determination of intracellular quercetin uptake using erythrocyte model and its implications in human aging.3 Biotech · 2018Article
- Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease.Cellular and molecular life sciences : CMLS · 2018Review
- Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats.BMC complementary and alternative medicine · 2017Article
- Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: influence of interleukin-6/6R gene polymorphisms on inflammatory markers.Journal of inflammation research · 2017Article
- Article
- Antidepressant Flavonoids and Their Relationship with Oxidative Stress.Oxidative medicine and cellular longevity · 2017Review
- Observational
- Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin.Protoplasma · 2016Article
- Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura.BMC complementary and alternative medicine · 2016Article
- Co-delivery with nano-quercetin enhances doxorubicin-mediated cytotoxicity against MCF-7 cells.Molecular biology reports · 2016Article
- Systemic alcohol-protective effects of quercetin besides its ameliorating effect on alcohol-induced neuropathic pain.Inflammopharmacology · 2012Article
- Potential in vitro Protective Effect of Quercetin, Catechin, Caffeic Acid and Phytic Acid against Ethanol-Induced Oxidative Stress in SK-Hep-1 Cells.Biomolecules & therapeutics · 2012Article
- Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl.PloS one · 2012Article
- Effects of ceftriaxone on systemic and central expression of anti- and pro-inflammatory cytokines in alcohol-preferring (P) rats exposed to ethanol.Alcohol and alcoholism (Oxford, Oxfordshire)Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term alcohol consumption can cause oxidative stress and cytokines induction, which are associated with free radicals. Quercetin, one of the most widely distributed flavonoids in plants, is a natural antioxidant. We investigated the hypothesis that quercetin could prevent the ethanol-induced oxidative stress and decreases tumor necrosis factor-α (TNF-α) and interferon-γ (INF-γ) as pro-inflammatory cytokines. Twenty-eight rats were randomly divided into control group (C), ethanol treatment group (EtOH) (~1 ml/day, 80%; 2 g/kg body wt), intragastrically (i.g.), quercetin treatment group (Q), (100 mg/kg-body wt per 3 days) i.g. and ethanol plus quercetin treatment group (EtOH + Q) (1 ml/day, 80% of ethanol and 100 mg/kg-body wt of quercetin per 3 days) i.g. for 30 days Plasma thiobarbituric acid reactive substance (TBARS) levels and protein carbonyl content were significantly higher in the EtOH group than the C group (P < 0.01). On the other hand, TBARS level and protein carbonyl content in the EtOH + Q group was decreased significantly by quercetin (P < 0.05, P < 0.01; respectively). While GSH levels in whole blood decreased in EtOH group compared to C group, they increased significantly by quercetin (P < 0.05). Plasma ALT, TNF-α and IFN-γ levels increased significantly in the EtOH group compared to control group (P < 0.05, P < 0.01, P < 0.01, respectively), but they decreased significantly in the EtOH + Q group in comparison with EtOH group (P < 0.05, P < 0.01, P < 0.01, respectively). Our results demonstrate that quercetin treatment may provide a protection as reflected by decreased plasma TBARS, protein carbonyls, TNF-α, INF-γ and ALT levels against ethanol-induced oxidative damage.
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