ReviewEuropean journal of pediatrics2011
Acute hemorrhagic edema of young children: a concise narrative review.
Review in European journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- COVID-19 associated pediatric vasculitis: A systematic review and detailed analysis of the pathogenesis.Seminars in arthritis and rheumatism · 2022Pooled it
- Article
- Accurate diagnosis of acute hemorrhagic edema of infancy: a French multicenter observational study.European journal of pediatrics · 2023Observational
- Infant with a rapidly progressing rash.BMJ case reports · 2021Article
- Acute haemorrhagic oedema of infancy: a condition that is not always benign.BMJ case reports · 2020Article
- Targetoid Skin Lesions in a Child: Acute Hemorrhagic Oedema of Infancy and Its Differential Diagnosis.International journal of environmental research and public health · 2019Article
- Cutaneous Manifestations of Small-Vessel Leukocytoclastic Vasculitides in Childhood.Clinical reviews in allergy & immunology · 2017Review
- Acute hemorrhagic edema of young children: a prospective case series.European journal of pediatrics · 2016Article
- Purpuric lesions: what diagnosis?BMJ case reports · 2016Article
- Methylprednisolone therapy in acute hemorrhagic edema of infancy.Case reports in dermatological medicine · 2014Article
- Leukocytoclastic vasculitis presenting with acute haemorrhagic oedema of the scrotum.BMJ case reports · 2011Article
- Acute hemorrhagic edema of infancy (Finkelstein's disease): favorable outcome with systemic steroids in a female patient.Anais brasileiros de dermatologiaArticle
- Acute hemorrhagic edema of infancy after MMR vaccine.Annals of Saudi medicineArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute hemorrhagic edema of young children is an uncommon but likely underestimated cutaneous leukocytoclastic vasculitis. The condition typically affects infants 6-24 months of age with a history of recent respiratory illness with or without course of antibiotics. The diagnosis is made in children, mostly nontoxic in appearance, presenting with nonpruritic, large, round, red to purpuric plaques predominantly over the cheeks, ears, and extremities, with relative sparing of the trunk, often with a target-like appearance, and edema of the distal extremities, ears, and face that is mostly non-pitting, indurative, and tender. In boys, the lesions sometimes involve the scrotum and, more rarely, the penis. Fever, typically of low grade, is often present. Involvement of body systems other than skin is uncommon, and spontaneous recovery usually occurs within 6-21 days without sequelae. In this condition, laboratory tests are non-contributory: total blood cell count is often normal, although leukocytosis and thrombocytosis are sometimes found, clotting studies are normal, erythrocyte sedimentation rate and C-reactive protein test are normal or slightly elevated, complement level is normal, autoantibodies are absent, and urinalysis is usually normal. Experienced physicians rapidly consider the possible diagnosis of acute hemorrhagic edema when presented with a nontoxic young child having large targetoid purpuric lesions and indurative swelling, which is non-pitting in character, and make the diagnosis either on the basis of clinical findings alone or supported by a skin biopsy study.
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Registered trials
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