ArticlePloS one2011
CD40 signaling synergizes with TLR-2 in the BCR independent activation of resting B cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Review
- Review
- Nanomaterials-Mediated Co-Stimulation of Toll-Like Receptors and CD40 for Antitumor Immunity.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- TLR2 deficiency promotes IgE and inhibits IgG1 class-switching following ovalbumin sensitization.Italian journal of pediatrics · 2021Article
- B Cell Recognition ofFrontiers in immunology · 2021Article
- AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression.Frontiers in oncology · 2021Review
- The Nod2 Agonist Muramyl Dipeptide Cooperates with the TLR4 Agonist Lipopolysaccharide to Enhance IgG2b Production in Mouse B Cells.Journal of immunology research · 2019Article
- Age-Related Changes on CD40 Promotor Methylation and Immune Gene Expressions in Thymus of Chicken.Frontiers in immunology · 2018Article
- Combination of poly I:C and Pam3CSK4 enhances activation of B cells in vitro and boosts antibody responses to protein vaccines in vivo.PloS one · 2017Article
- Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells.Innate immunity · 2016Article
- The Role of TLR4 on B Cell Activation and Anti-Journal of immunology research · 2016Review
- Crosstalk between innate and adaptive immunity in hepatitis B virus infection.World journal of hepatology · 2015Review
- Toll-like receptor 2 activators modulate oral tolerance in mice.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
- Article
- New frontiers for platelet CD154.Experimental hematology & oncology · 2015Article
- Toll-like receptors in the pathogenesis of human B cell malignancies.Journal of hematology & oncology · 2014Review
- Toll-like receptors and B cells: functions and mechanisms.Immunologic research · 2014Review
- Article
- Toll-like receptor 2 as a regulator of oral tolerance in the gastrointestinal tract.Mediators of inflammation · 2014Review
- The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro.BMC genomics · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventionally, signaling through BCR initiates sequence of events necessary for activation and differentiation of B cells. We report an alternative approach, independent of BCR, for stimulating resting B (RB) cells, by involving TLR-2 and CD40--molecules crucial for innate and adaptive immunity. CD40 triggering of TLR-2 stimulated RB cells significantly augments their activation, proliferation and differentiation. It also substantially ameliorates the calcium flux, antigen uptake capacity and ability of B cells to activate T cells. The survival of RB cells was improved and it increases the number of cells expressing activation induced deaminase (AID), signifying class switch recombination (CSR). Further, we also observed increased activation rate and decreased threshold period required for optimum stimulation of RB cells. These results corroborate well with microarray gene expression data. This study provides novel insights into coordination between the molecules of innate and adaptive immunity in activating B cells, in a BCR independent manner. This strategy can be exploited to design vaccines to bolster B cell activation and antigen presenting efficiency, leading to faster and better immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.