ArticlePloS one2011
Association of ORAI1 haplotypes with the risk of HLA-B27 positive ankylosing spondylitis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.PloS one · 2013Trial
- Article
- Immunogenetics of Kawasaki disease.Clinical reviews in allergy & immunology · 2020Review
- MUTYH and ORAI1 polymorphisms are associated with susceptibility to osteoarthritis in the Chinese Han population.The Journal of international medical research · 2018Article
- rs2841277 (Oncotarget · 2017Article
- rs657075 (CSF2) Is Associated with the Disease Phenotype (BAS-G) of Ankylosing Spondylitis.International journal of molecular sciences · 2017Article
- Variations in ORAI1 Gene Associated with Kawasaki Disease.PloS one · 2016Article
- The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese.BioMed research international · 2015Article
- Association Study of IL-12B Polymorphisms Susceptibility with Ankylosing Spondylitis in Mainland Han Population.PloS one · 2015Article
- Associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis.Rheumatology international · 2014Article
- ETS1 variants confer susceptibility to ankylosing spondylitis in Han Chinese.Arthritis research & therapy · 2014Article
- Identifying association model for single-nucleotide polymorphisms of ORAI1 gene for breast cancer.Cancer cell international · 2014Article
- A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis.Mediators of inflammation · 2014Article
- Single-nucleotide polymorphism rs7251246 in ITPKC is associated with susceptibility and coronary artery lesions in Kawasaki disease.PloS one · 2014Article
- Genetic polymorphisms of ORAI1 and chronic kidney disease in Taiwanese population.BioMed research international · 2014Article
- rs10865331 associated with susceptibility and disease severity of ankylosing spondylitis in a Taiwanese population.PloS one · 2014Article
- Lipopolysaccharide regulates biosynthesis of cystathionine γ-lyase and hydrogen sulfide through Toll-like receptor-4/p38 and Toll-like receptor-4/NF-κB pathways in macrophages.In vitro cellular & developmental biology. Animal · 2013Article
- Immunogenetic study in Chinese population with ankylosing spondylitis: are there specific genes recently disclosed?Clinical & developmental immunology · 2013Review
- ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations.PloS one · 2012Article
- Article
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The aetiology of ankylosing spondylitis is still unclear. Previous studies have indicated that genetics factors such as human leukocyte antigen HLA-B27 associates to AS susceptibility. We carried out a case-control study to determine whether the genetic polymorphisms of ORAI1 gene, a major component of store-operated calcium channels that involved the regulation of immune system, is a susceptibility factor to AS in a Taiwanese population. We enrolled 361 AS patients fulfilled the modified New York criteria and 379 controls from community. Five tagging single nucleotides polymorphisms (tSNPs) at ORAI1 were selected from the data of Han Chinese population in HapMap project. Clinical statuses of AS were assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Bath Ankylosing Spondylitis Global Index (BAS-G). Our results indicated that subjects carrying the minor allele homozygote (CC) of the promoter SNP rs12313273 or TT homozygote of the SNP rs7135617 had an increased risk of HLA-B27 positive AS. The minor allele C of 3'UTR SNP rs712853 exerted a protective effect to HLA-B27 positive AS. Furthermore, the rs12313273/rs7135617 pairwise allele analysis found that C-G (OR 1.69, 95% CI 1.27, 2.25; p = 0.0003) and T-T (OR 1.75, 95% CI 1.36, 2.27; p<0.0001) haplotypes had a significantly association with the risk of HLA-B27-positive AS in comparison with the T-G carriers. This is the first study that indicate haplotypes of ORAI1 (rs12313273 and rs7135617) are associated with the risk of HLA-B27 positive AS.
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