ArticlePloS one2011
Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer's disease.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Vascular endothelial growth factor gene promoter polymorphisms and Alzheimer's disease risk: a meta-analysis.CNS neuroscience & therapeutics · 2013Pooled it
- SLAMF8 and NINJ2 promote neuroinflammation and oxidative stress through TLR4 NF kappa B pathway in Alzheimer's disease.Scientific reports · 2025Article
- Recent Advances in the Treatment and Management of Alzheimer's Disease: A Precision Medicine Perspective.Current topics in medicinal chemistry · 2024Review
- Age‑related brainstem degeneration through microRNA modulation in mice.Molecular medicine reports · 2023Article
- Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk.Open medicine (Warsaw, Poland) · 2023Article
- Article
- Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk.Cancer cell international · 2021Article
- Assessment of Association between NINJ2 Polymorphisms and Suicide Attempts in an Iranian Population.Journal of molecular neuroscience : MN · 2020Article
- Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders.Journal of molecular neuroscience : MN · 2020Article
- Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis.Neurotoxicology · 2018Article
- Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren.Scientific reports · 2015Article
- Genes underlying positive influence of prenatal environmental enrichment and negative influence of prenatal earthquake simulation and corrective influence of Chinese herbal medicine on rat offspring: Irf7 and Ninj2.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2014Article
- Polymorphism -116C/G of human X-box-binding protein 1 promoter is associated with risk of Alzheimer's disease.CNS neuroscience & therapeutics · 2013Article
- CHRNA7 polymorphisms and response to cholinesterase inhibitors in Alzheimer's disease.PloS one · 2013Article
- Aberrant methylation of gene associated CpG sites occurs in borderline personality disorder.PloS one · 2013Article
- Mechanism of earthquake simulation as a prenatal stressor retarding rat offspring development and chinese medicine correcting the retardation: hormones and gene-expression alteration.Evidence-based complementary and alternative medicine : eCAM · 2012Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccumulated evidences have shown that vascular risk factors, e.g., hypertension, diabetes mellitus and hyperlipidemia, may be related to the risk of dementia. This study investigated the association between genetic polymorphisms of a vascular susceptibility gene, Ninjurin2 (NINJ2), and the risk of dementia, which has not been explored previously.
methodsA total of 275 Alzheimer's disease (AD) patients and 119 vascular dementia (VaD) patients aged 50 or older were recruited from three teaching hospitals from 2007 to 2010. Healthy controls (n = 423) with the same age of cases were recruited from the health checkup and volunteers worked at the hospital during the same time period. Five common (frequency >5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) in NINJ2 were genotyped to test for the association between sequence variants of NINJ2 and dementia risk, and how vascular risk factors modify this association.
resultsHomozygosity of two NINJ2 SNPs was significantly associated with a decreased risk of AD [rs11833579: adjusted odds ratio (AOR) = 0.43; 95% confidence interval (CI)= 0.23-0.80; rs12425791: AOR= 0.33, 95% CI= 0.12-0.96]. Five common haplotypes (cumulative frequency= 97%) were identified. The global test for the association between NINJ2 haplotypes and AD was significant (p = 0.03). Haplotype CAGGA was significantly associated with a decreased risk of AD (AOR= 0.32, 95% CI= 0.11-0.94). No associations were observed for VaD.
conclusionInherited polymorphisms of the vascular susceptibility gene NINJ2 were associated with AD risk.
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