ArticleMarine drugs2011
Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp.
Article in Marine drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Synthesis and Biological Evaluation of 4‑Bromo-ACS omega · 2026Article
- Discovery of Peptidic Siderophore Degradation by Screening Natural Product Profiles in Marine-Derived Bacterial Mono- and Cocultures.Biochemistry · 2025Article
- Review
- Article
- Terpenes extracted from marine sponges with antioxidant activity: a systematic review.Natural products and bioprospecting · 2023Review
- Secondary Metabolites from the Cultures of Medicinal MushroomJournal of fungi (Basel, Switzerland) · 2023Article
- Recent Advances of Marine Natural Indole Products in Chemical and Biological Aspects.Molecules (Basel, Switzerland) · 2023Review
- Synthesis, characterization, andRSC advances · 2023Article
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- Application of Marine Microbial Natural Products in Cosmetics.Frontiers in microbiology · 2022Review
- Volatile Organic Compounds, Indole, and Biogenic Amines Assessment in Two Mediterranean Irciniidae (Porifera, Demospongiae).Marine drugs · 2021Article
- Hypaphorine exerts anti-inflammatory effects in sepsis induced acute lung injury via modulating DUSP1/p38/JNK pathway.The Kaohsiung journal of medical sciences · 2021Article
- Biosynthesis and synthetic biology of psychoactive natural products.Chemical Society reviews · 2021Review
- New Cytotoxic Cerebrosides from the Red Sea CucumberMarine drugs · 2020Article
- Article
- Article
- Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific SpongeMarine drugs · 2019Article
- A new antitrypanosomal alkaloid from the Red Sea marine sponge Hyrtios sp.The Journal of antibiotics · 2018Article
- Bioactive Natural Products of Marine Sponges from the Genus Hyrtios.Molecules (Basel, Switzerland) · 2017Review
- Marine Indole Alkaloids.Marine drugs · 2015Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A₂ (PLA₂), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA₂ inhibition (IC₅₀ 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.