ArticlePloS one2011
Fibro-vascular coupling in the control of cochlear blood flow.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Aspirin in Audiology: A Dual-Edged Sword in Hearing Loss and Its Nanotechnology-Driven Future.Drug design, development and therapy · 2026Review
- Norepinephrine protects against cochlear outer hair cell damage and noise-induced hearing loss via αBMC neuroscience · 2024Article
- Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset.iScience · 2023Article
- Research advances in cochlear pericytes and hearing loss.Hearing research · 2023Review
- Review
- Neutrophils infiltrate into the spiral ligament but not the stria vascularis in the cochlea during lipopolysaccharide-induced inflammation.Theranostics · 2021Article
- Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere's disease.Journal of otology · 2020Article
- The mechanoelectrical transducer channel is not required for regulation of cochlear blood flow during loud sound exposure in mice.Scientific reports · 2020Article
- On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament.Frontiers in neurology · 2020Review
- Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier.Science translational medicine · 2019Review
- Forgotten Fibrocytes: A Neglected, Supporting Cell Type of the Cochlea With the Potential to be an Alternative Therapeutic Target in Hearing Loss.Frontiers in cellular neuroscience · 2019Article
- Human inner ear blood supply revisited: the Uppsala collection of temporal bone-an international resource of education and collaboration.Upsala journal of medical sciences · 2018Article
- Platelet-Derived Growth Factor Subunit B Signaling Promotes Pericyte Migration in Response to Loud Sound in the Cochlear Stria Vascularis.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Oxidative Stress in the Blood Labyrinthine Barrier in the Macula Utricle of Meniere's Disease Patients.Frontiers in physiology · 2018Article
- The redox protein p66(shc) mediates cochlear vascular dysfunction and transient noise-induced hearing loss.Scientific reports · 2016Article
- Noise-Induced "Toughening" Effect in Wistar Rats: Enhanced Auditory Brainstem Responses Are Related to Calretinin and Nitric Oxide Synthase Upregulation.Frontiers in neuroanatomy · 2016Article
- Two-photon microscopy allows imaging and characterization of cochlear microvasculature in vivo.BioMed research international · 2015Article
- Thin and open vessel windows for intra-vital fluorescence imaging of murine cochlear blood flow.Hearing research · 2014Article
- Identification of a gene set to evaluate the potential effects of loud sounds from seismic surveys on the ears of fishes: a study with Salmo salar.Journal of fish biology · 2014Article
- Symphony of vascular contraction: how smooth muscle cells lose harmony to signal increased vascular resistance in hypertension.Hypertension (Dallas, Tex. : 1979) · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundTransduction of sound in the cochlea is metabolically demanding. The lateral wall and hair cells are critically vulnerable to hypoxia, especially at high sound levels, and tight control over cochlear blood flow (CBF) is a physiological necessity. Yet despite the importance of CBF for hearing, consensus on what mechanisms are involved has not been obtained. METHODOLOGY/PRINCIPAL
findingsWe report on a local control mechanism for regulating inner ear blood flow involving fibrocyte signaling. Fibrocytes in the super-strial region are spatially distributed near pre-capillaries of the spiral ligament of the albino guinea pig cochlear lateral wall, as demonstrably shown in transmission electron microscope and confocal images. Immunohistochemical techniques reveal the inter-connected fibrocytes to be positive for Na+/K+ ATPase β1 and S100. The connected fibrocytes display more Ca(2+) signaling than other cells in the cochlear lateral wall as indicated by fluorescence of a Ca(2+) sensor, fluo-4. Elevation of Ca(2+) in fibrocytes, induced by photolytic uncaging of the divalent ion chelator o-nitrophenyl EGTA, results in propagation of a Ca(2+) signal to neighboring vascular cells and vasodilation in capillaries. Of more physiological significance, fibrocyte to vascular cell coupled signaling was found to mediate the sound stimulated increase in cochlear blood flow (CBF). Cyclooxygenase-1 (COX-1) was required for capillary dilation. CONCLUSIONS/SIGNIFICANCE: The findings provide the first evidence that signaling between fibrocytes and vascular cells modulates CBF and is a key mechanism for meeting the cellular metabolic demand of increased sound activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.