Evidence map›Paper›PMID 2167366›Full record

ArticleThe Journal of physiology1990

Vasoactive intestinal peptide stimulation of human renal adenylate cyclase in vitro.

B G Charlton, D E Neal, N L Simmons

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

B G CharltonDepartment of Physiological Sciences, the Medical School, University of Newcastle upon Tyne, NE2 4HH.
D E Neal
N L Simmons
Department of Physiological Sciences · RU

Funding

Wellcome Trust
6 · The paper itself

Abstract

1. A direct action of vasoactive intestinal peptide (VIP) upon human kidney was sought by measurement of renal adenylate cyclase in tissue homogenates and plasma membranes isolated from tissue samples excised for therapeutic reasons. 2. VIP (1 microM) produced a mean stimulation of adenylate cyclase activity of 3.5-fold compared to basal values in cortical plasma membranes; comparative stimulations of 2.8-fold and 27.3-fold were obtained with 1 microM-glucagon and 1 microM-h(1-34) parathyroid hormone respectively. 3. Half-maximal stimulation of human renal cortical plasma membrane adenylate cyclase was observed with a mean value of 35 nM-VIP. 4. The stimulation of renal adenylate cyclase by VIP appeared to be specific because stimulation by glucagon was additive to that obtained with VIP, and the VIP receptor antagonist (4 Cl-D-Phe6, Leu17)-VIP inhibited the VIP-dependent stimulation of adenylate cyclase activity.

Indexed as

Adenylyl CyclasesCell MembraneFemaleGlucagonHumansIn Vitro TechniquesKidneyMaleReceptors, Gastrointestinal HormoneReceptors, Vasoactive Intestinal PeptideVasoactive Intestinal PeptideAdenylyl CyclasesGlucagonReceptors, Gastrointestinal HormoneReceptors, Vasoactive Intestinal PeptideVasoactive Intestinal Peptidevasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-

Identifiers

PMID2167366
PMCPMC1189769
OpenAlexW2080500055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.