ArticlePlant physiology2011
Increase in tomato locule number is controlled by two single-nucleotide polymorphisms located near WUSCHEL.
Article in Plant physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers.
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170 citing papers in PubMed, 347 citations in OpenAlex.
- Multi-variant GWAS and genomic prediction dissect the genetic architecture underlying tomato fruit weight.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- CRISPR/Cas9-Mediated Knockout of LbSP1 and LbSP5G1 Reveals Efficient Customization of Shoot Architecture in Black Goji Berry.Plant biotechnology journal · 2026Article
- Advances in genomics-driven genetic decoding and genomic design breeding in tomato.Horticulture research · 2026Article
- Insights into Candidate Pathways Associated with Multi-Pistil Formation in Chinese Chestnut (Biology · 2026Article
- Newly found functions and regulatory networks of WOX family: what else does the WOX say?Planta · 2026Review
- Natural variation in SlGRF10 reveals a role in regulating tomato fruit weight.Plant physiology · 2026Article
- Protein Phosphorylation: An Essential Role in Shoot Apical Meristem Homeostasis.Plants (Basel, Switzerland) · 2026Review
- Review
- Splicing regulation by RS2Z36 controls ovary patterning and fruit growth in tomato.Plant molecular biology · 2026Article
- Rare Natural SNP Activates SHOOT APICAL MERISTEM ENLARGER1 to Increase Branch Number and Silique Number on the Main Inflorescence in Brassica napus.Plant biotechnology journal · 2026Article
- The G protein-casein kinase 2 module acts as a pivot in plasma membrane-to-nucleus CLAVATA signaling to control shoot apical meristem size.Nature communications · 2026Article
- WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Molecular Regulatory Mechanism of Inflorescence, Flower and Fruit Development in Tomato.Plants (Basel, Switzerland) · 2026Review
- Reproductive Diversity in Cultivated Tomato (Plants (Basel, Switzerland) · 2026Article
- Haplotype-based genome-wide association study uncovers QTL for fruit-related traits in the 287 tomato accessions.BMC plant biology · 2026Article
- Fruit weight regulation by a paralog of Cell Size Regulator (CSR) in tomato and other crops.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Novel genome editing approaches to manipulate apical meristem activity for crop yield.Frontiers in plant science · 2026Review
- Association mapping of tomato fruit quality for weight, firmness, brix, and color using GWAS.BMC plant biology · 2025Article
- Identification of major loci governing 13 agronomic traits and the fine-mapping of CaSUN29 regulating fruit length in pepper.Molecular horticulture · 2025Article
- Transcriptional control of tomato fruit development and ripening.Journal of experimental botany · 2025Review
110 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In tomato (Solanum lycopersicum) fruit, the number of locules (cavities containing seeds that are derived from carpels) varies from two to up to 10 or more. Locule number affects fruit shape and size and is controlled by several quantitative trait loci (QTLs). The large majority of the phenotypic variation is explained by two of these QTLs, fasciated (fas) and locule number (lc), that interact epistatically with one another. FAS has been cloned, and mutations in the gene are described as key factors leading to the increase in fruit size in modern varieties. Here, we report the map-based cloning of lc. The lc QTL includes a 1,600-bp region that is located 1,080 bp from the 3' end of WUSCHEL, which encodes a homeodomain protein that regulates stem cell fate in plants. The molecular evolution of lc showed a reduction of diversity in cultivated accessions with the exception of two single-nucleotide polymorphisms. These two single-nucleotide polymorphisms were shown to be responsible for the increase in locule number. An evolutionary model of locule number is proposed herein, suggesting that the fas mutation appeared after the mutation in the lc locus to confer the extreme high-locule-number phenotype.
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