ArticlePhysiological genomics2011
Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia.
Article in Physiological genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- The Physiological and Pharmacological Significance of the Circadian Timing of the HPA Axis: A Mathematical Modeling Approach.Journal of pharmaceutical sciences · 2024Review
- Mathematical modeling of mammalian circadian clocks affecting drug and disease responses.Journal of pharmacokinetics and pharmacodynamics · 2021Review
- A novel heart rate variability based risk prediction model for septic patients presenting to the emergency department.Medicine · 2018Observational
- Modeling the Influence of Seasonal Differences in the HPA Axis on Synchronization of the Circadian Clock and Cell Cycle.Endocrinology · 2018Article
- Daily variation of gene expression in diverse rat tissues.PloS one · 2018Article
- Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat.PloS one · 2018Article
- A Model-Based Machine Learning Approach to Probing Autonomic Regulation From Nonstationary Vital-Sign Time Series.IEEE journal of biomedical and health informatics · 2018Article
- On the analysis of complex biological supply chains: From Process Systems Engineering to Quantitative Systems Pharmacology.Computers & chemical engineering · 2017Article
- A data-driven modeling approach to identify disease-specific multi-organ networks driving physiological dysregulation.PLoS computational biology · 2017Article
- Autonomic function and brain volume.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Review
- The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity.Physiological genomics · 2016Article
- Sepsis in standard care: patients' characteristics, effectiveness of antimicrobial therapy and patient outcome--a cohort study.Infection · 2015Observational
- Human metabolic response to systemic inflammation: assessment of the concordance between experimental endotoxemia and clinical cases of sepsis/SIRS.Critical care (London, England) · 2015Article
- Physiologic variability at the verge of systemic inflammation: multiscale entropy of heart rate variability is affected by very low doses of endotoxin.Shock (Augusta, Ga.) · 2015Article
- Circadian characteristics of permissive and suppressive effects of cortisol and their role in homeostasis and the acute inflammatory response.Mathematical biosciences · 2015Article
- A Chemical Engineer's Perspective on Health and Disease.Computers & chemical engineering · 2014Article
- On heart rate variability and autonomic activity in homeostasis and in systemic inflammation.Mathematical biosciences · 2014Article
- Predicting critical transitions in a model of systemic inflammation.Journal of theoretical biology · 2013Article
- Temporal metabolic profiling of plasma during endotoxemia in humans.Shock (Augusta, Ga.) · 2013Article
- Translational applications of evaluating physiologic variability in human endotoxemia.Journal of clinical monitoring and computing · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Heart rate variability (HRV), the quantification of beat-to-beat variability, has been studied as a potential prognostic marker in inflammatory diseases such as sepsis. HRV normally reflects significant levels of variability in homeostasis, which can be lost under stress. Much effort has been placed in interpreting HRV from the perspective of quantitatively understanding how stressors alter HRV dynamics, but the molecular and cellular mechanisms that give rise to both homeostatic HRV and changes in HRV have received less focus. Here, we develop a mathematical model of human endotoxemia that incorporates the oscillatory signals giving rise to HRV and their signal transduction to the heart. Connections between processes at the cellular, molecular, and neural levels are quantitatively linked to HRV. Rhythmic signals representing autonomic oscillations and circadian rhythms converge to modulate the pattern of heartbeats, and the effects of these oscillators are diminished in the acute endotoxemia response. Based on the semimechanistic model developed herein, homeostatic and acute stress responses of HRV are studied in terms of these oscillatory signals. Understanding the loss of HRV in endotoxemia serves as a step toward understanding changes in HRV observed clinically through translational applications of systems biology based on the relationship between biological processes and clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.