ArticleThe Journal of infectious diseases2011
Number of years of annual mass treatment with azithromycin needed to control trachoma in hyper-endemic communities in Tanzania.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Dose and formulation of azithromycin in mass drug administration studies: a systematic review protocol.BMJ paediatrics open · 2019Pooled it
- Cohort and age effects of mass drug administration on prevalence of trachoma: a longitudinal study in rural Tanzania.Investigative ophthalmology & visual science · 2014Trial
- Can we stop mass drug administration prior to 3 annual rounds in communities with low prevalence of trachoma?: PRET Ziada trial results.JAMA ophthalmology · 2013Trial
- A randomized trial of two coverage targets for mass treatment with azithromycin for trachoma.PLoS neglected tropical diseases · 2013Trial
- Trachoma.Lancet (London, England) · 2025Review
- Article
- Comparison of metrics for assessing face washing behaviour for trachoma control.PLoS neglected tropical diseases · 2024Article
- Forecasting the elimination of active trachoma: An empirical model.PLoS neglected tropical diseases · 2022Article
- Understanding hard-to-reach communities: local perspectives and experiences of trachoma control among the pastoralist Maasai in northern Tanzania.Journal of biosocial science · 2021Article
- Low prevalence of active trachoma and associated factors among children aged 1-9 years in rural communities of Metema District, Northwest Ethiopia: a community based cross-sectional study.Italian journal of pediatrics · 2021Article
- Prevalence and associated factors of active trachoma among 1-9 years old children in Deguatemben, Tigray, Ethiopia, 2018: community cross-sectional study.BMC ophthalmology · 2020Article
- Progress to Eliminate Trachoma as a Public Health Problem in Amhara National Regional State, Ethiopia: Results of 152 Population-Based Surveys.The American journal of tropical medicine and hygiene · 2019Article
- Evidence for contamination with C. trachomatis in the household environment of children with active Trachoma: A cross-sectional study in Kongwa, Tanzania.PLoS neglected tropical diseases · 2019Article
- Toward the Elimination of Disease: the 2019 Weisenfeld Award Lecture.Investigative ophthalmology & visual science · 2019Article
- Ocular Chlamydia trachomatis infection: elimination with mass drug administration.Expert review of anti-infective therapy · 2019Review
- Coverage, social mobilization and challenges of mass Zithromax administration campaign in South and South East zones of Tigray, Northern Ethiopia: A cross sectional study.PLoS neglected tropical diseases · 2018Article
- The impact of a single round of community mass treatment with azithromycin on disease severity and ocular Chlamydia trachomatis load in treatment-naïve trachoma-endemic island communities in West Africa.Parasites & vectors · 2017Article
- Progress and projections in the program to eliminate trachoma.PLoS neglected tropical diseases · 2017Article
- Article
- Prevalence and associated factors of active trachoma among childeren aged 1-9 years in rural communities of Gonji Kolella district, West Gojjam zone, North West Ethiopia.BMC research notes · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe World Health Organization recommends mass treatment as part of a trachoma control strategy. However, scant empirical data from hyperendemic communities exist on the number of rounds of treatment needed to reach a goal of <5% prevalence in children. We determined the prevalence of trachoma and infection with Chlamydia trachomatis in communities after 3-7 years of annual mass treatment in Tanzania.
methodsSeventy-one communities with trachoma and annual azithromycin coverage data were enrolled. A cross-sectional survey of ≥100 randomly selected children aged <5 years in each community was performed. Children were examined for clinical trachoma, and swab samples were taken for determination of ocular C. trachomatis infection.
resultsAfter 3 years of mass treatment, the prevalence of trachoma decreased in a linear fashion with number of years of mass treatment, whereas decreased prevalences of C. trachomatis infection were related to the extent of the previous year's azithromycin coverage. Our model suggests that, for communities with baseline trachoma prevalence of 50% and annual treatment coverage of 75%, >7 years of annual mass treatment will be needed to reach a prevalence of trachoma of <5%.
conclusionsCountry programs in trachoma-endemic regions must realistically expect that several years of annual mass treatment may be necessary to eliminate trachoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.