Evidence map›Paper›PMID 21673030›Full record

ArticleThe Journal of infectious diseases2011

Serum antibody response following genital {alpha}9 human papillomavirus infection in young men.

Zoe R Edelstein, Joseph J Carter, Ruchi Garg, Rachel L Winer, Qinghua Feng, Denise A Galloway, Laura A Koutsky

Open access · greenAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Humoral Response to HPV16 Proteins in Persons with Anal High-Grade Squamous Intraepithelial Lesion or Anal Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  9. Article
  10. Article
  11. Should female sex workers be offered HPV vaccination?Human vaccines & immunotherapeutics · 2019
    Review
  12. Review
  13. Cutaneous HPV and alpha-mucosal 9-valent HPV sero-status associations.Papillomavirus research (Amsterdam, Netherlands) · 2017
    Article
  14. Tumour virus vaccines: hepatitis B virus and human papillomavirus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zoe R EdelsteinDepartment of Epidemiology, University of Washington, Box 359933, HPV Research Group, 908 Jefferson, Suite 1191, Seattle, WA 98104 , USA.
Joseph J Carter
Ruchi Garg
Rachel L Winer
Qinghua Feng
Denise A Galloway
Laura A Koutsky
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MILTON L WAINBERG · 2003 to 2026
$48.2M
HPV CAPSID ANTIBODIESR01AI038382 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GALLOWAY, DENISE A. · 1995 to 2020
$4.4M
Natural History of HPV Infections in MenR01CA105181 · NCI · UNIVERSITY OF WASHINGTON · PI KOUTSKY, LAURA A · 2005 to 2009
$3.3M
HPV CAPSID ANTIBODIESR37AI038382 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GALLOWAY, DENISE A. · 2000 to 2009
$3.0M
NCI NIH HHS R01 CA105181NIAID NIH HHS R01 AI038382NIAID NIH HHS R37 AI038382NIMH NIH HHS P30 MH043520
6 · The paper itself

Abstract

Background. Although the prevalence of human papillomavirus (HPV) genital infection is similarly high in males and females, seroprevalence is lower in males. This study assessed rates and determinants of seroconversion after detection of genital HPV infection in young men. Methods. We investigated HPV type-specific seroconversion in a cohort of heterosexual male university students who had an α9 HPV type (HPV-16, -31, -33, -35, -52, -58, or -67) detected in the genital tract (n = 156). HPV DNA and antibodies were detected and typed using liquid bead-based multiplex assays. We calculated seroconversion using Kaplan-Meier survival analysis. Cox proportional hazards models with generalized estimating equations were used to examine associations with seroconversion. Results. Within 24 months of detecting genital HPV infection, type-specific seroconversion ranged from 4% for HPV-52 to 36% for HPV-31. HPV-16 seroconversion at 24 months was 13% (95% confidence interval [CI], 7%-25%). Among incident HPV infections, ever cigarette smoking and infection site(s) (shaft/scrotum and glans/urine vs shaft/scrotum or glans/urine only) were positively associated with type-specific seroconversion. Conclusions. For each of the α9 HPV types, type-specific seroconversion within 24 months was observed in 36% or less of infected men. Seroconversion might be related to cigarette smoking and genital site(s) infected.

Indexed as

AdolescentAntibodies, ViralCohort StudiesDNA, ViralGenital Diseases, MaleHumansMalePapillomaviridaePapillomavirus InfectionsSerumStudentsYoung AdultAntibodies, ViralDNA, Viral

Identifiers

PMID21673030
PMCPMC3114468
OpenAlexW2153855152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.