Evidence map›Paper›PMID 21672910›Full record

Trial reportJournal of the American Medical Informatics Association : JAMIA

Targeted screening for pediatric conditions with the CHICA system.

Aaron E Carroll, Paul G Biondich, Vibha Anand, Tamara M Dugan, Meena E Sheley, Shawn Z Xu, Stephen M Downs

3 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Medical Informatics Association : JAMIA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
9.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02546752 early_phase1completednot on this map

Use of a Patient Education/Messaging Platform to Increase Uptake and Series Completion of the HPV Vaccine

TypeinterventionalSponsorRegenstrief Institute, Inc.Ran2015 to 2016Enrolled1,306ConditionsHuman Papilloma Virus Infection Type 11, Human Papilloma Virus Infection Type 16, Human Papilloma Virus Infection Type 18, Human Papilloma Virus Infection Type 6ArmsTHEO
NCT02551887 nacompletednot on this map

HPV Vaccination: An Investigation of Physician Reminders and Recommendation Scripts

TypeinterventionalSponsorRegenstrief Institute, Inc.Ran2014 to 2015Enrolled647ConditionsHuman Papilloma Virus Infection Type 11, Human Papilloma Virus Infection Type 16, Human Papilloma Virus Infection Type 18, Human Papilloma Virus Infection Type 6ArmsAutomated Reminder, Automated Reminder Plus Script
NCT02558803 nacompletednot on this map

HPV Vaccination: Evaluation of Reminder Prompts for Doses 2 & 3

TypeinterventionalSponsorRegenstrief Institute, Inc.Ran2015 to 2016Enrolled1,305ConditionsHuman Papilloma Virus Infection Type 11, Human Papilloma Virus Infection Type 16, Human Papilloma Virus Infection Type 18, Human Papilloma Virus Infection Type 6ArmsSimple Reminder
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 44 citations in OpenAlex.

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  10. Pediatric decision support using adapted Arden Syntax.Artificial intelligence in medicine · 2018
    Article
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  16. Possibilities and Implications of Using the ICF and Other Vocabulary Standards in Electronic Health Records.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2015
    Review
  17. Data visualization for truth maintenance in clinical decision support systems.International journal of pediatrics & adolescent medicine · 2015
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Aaron E CarrollChildren's Health Services Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. aaecarro@iupui.edu
Paul G Biondich
Vibha Anand
Tamara M Dugan
Meena E Sheley
Shawn Z Xu
Stephen M Downs
Indiana University School of MedicineRegenstrief Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe Child Health Improvement through Computer Automation (CHICA) system is a decision-support and electronic-medical-record system for pediatric health maintenance and disease management. The purpose of this study was to explore CHICA's ability to screen patients for disorders that have validated screening criteria--specifically tuberculosis (TB) and iron-deficiency anemia.

designChildren between 0 and 11 years were randomized by the CHICA system. In the intervention group, parents were asked about TB and iron-deficiency risk, and physicians received a tailored prompt. In the control group, no screens were performed, and the physician received a generic prompt about these disorders.

results1123 participants were randomized to the control group and 1116 participants to the intervention group. Significantly more people reported positive risk factors for iron-deficiency anemia in the intervention group (17.5% vs 3.1%, OR 6.6, 95% CI 4.5 to 9.5). In general, far fewer parents reported risk factors for TB than for iron-deficiency anemia. Again, there were significantly higher detection rates of positive risk factors in the intervention group (1.8% vs 0.8%, OR 2.3, 95% CI 1.0 to 5.0). LIMITATIONS: It is possible that there may be more positive screens without improving outcomes. However, the guidelines are based on studies that have evaluated the questions the authors used as sensitive and specific, and there is no reason to believe that parents misunderstood them.

conclusionsMany screening tests are risk-based, not universal, leaving physicians to determine who should have a further workup. This can be a time-consuming process. The authors demonstrated that the CHICA system performs well in assessing risk automatically for TB and iron-deficiency anemia.

Indexed as

Decision Support Systems, ClinicalGuideline AdherenceAmbulatory Care Information SystemsAnemia, Iron-DeficiencyChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleMass ScreeningRisk AssessmentSensitivity and SpecificityTuberculosisUnited States

Identifiers

PMID21672910
PMCPMC3128399
OpenAlexW1919283446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.