ArticleMolecular and cellular endocrinology2011
Transcriptional regulation of the human KiSS1 gene.
Article in Molecular and cellular endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 67 citations in OpenAlex.
- Reactivation of the silencedProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evidence for KISS-1 nuclear translocation and PI3K/AKT signaling in the ultrastructurally and morphometrically analyzed human endometriosis.Frontiers in cell and developmental biology · 2025Article
- Consider CUX1 variants in children with a variation of sex development: a case report and review of the literature.BMC medical genomics · 2024Review
- Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms.JCI insight · 2023Article
- Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice.Nature communications · 2022Article
- Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice.Molecular and cellular endocrinology · 2022Article
- Localization and regulatory function of Yin Yang 1 (YY1) in chicken testis.Molecular genetics and genomics : MGG · 2022Article
- Article
- Kiss1 is differentially regulated in male and female mice by the homeodomain transcription factor VAX1.Molecular and cellular endocrinology · 2021Article
- Multi- and Transgenerational Outcomes of an Exposure to a Mixture of Endocrine-Disrupting Chemicals (EDCs) on Puberty and Maternal Behavior in the Female Rat.Environmental health perspectives · 2021Article
- Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression.Scientific reports · 2021Article
- MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons.The Journal of clinical investigation · 2020Article
- EAP1 regulation of GnRH promoter activity is important for human pubertal timing.Human molecular genetics · 2019Article
- Molecular and Environmental Mechanisms Regulating Puberty Initiation: An Integrated Approach.Frontiers in endocrinology · 2019Review
- SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression.Nature communications · 2018Article
- A dual fluorescence reporter system for high throughput screening of effectors ofFEBS open bio · 2018Article
- Hypothalamic epigenetics driving female puberty.Journal of neuroendocrinology · 2018Review
- Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty.Nature communications · 2018Article
- The Effect of Bisphenol A on Puberty: A Critical Review of the Medical Literature.International journal of environmental research and public health · 2017Review
- The Role of Kisspeptin in Female Reproduction.International journal of endocrinology and metabolism · 2017Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Kisspeptin, the product of the KiSS1 gene, has emerged as a key component of the mechanism by which the hypothalamus controls puberty and reproductive development. It does so by stimulating the secretion of gonadotropin releasing hormone (GnRH). Little is known about the transcriptional control of the KiSS1 gene. Here we show that a set of proteins postulated to be upstream components of a hypothalamic network involved in controlling female puberty regulates KiSS1 transcriptional activity. Using RACE-PCR we determined that transcription of KiSS1 mRNA is initiated at a single transcription start site (TSS) located 153-156bp upstream of the ATG translation initiation codon. Promoter assays performed using 293 MSR cells showed that the KiSS1 promoter is activated by TTF1 and CUX1-p200, and repressed by EAP1, YY1, and CUX1-p110. EAP1 and CUX-110 were also repressive in GT1-7 cells. All four TFs are recruited in vivo to the KiSS1 promoter and are expressed in kisspeptin neurons. These results suggest that expression of the KiSS1 gene is regulated by trans-activators and repressors involved in the system-wide control of mammalian puberty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.