ArticleAppetite2011
Dopamine polymorphisms and depressive symptoms predict foods intake. Results from a nationally representative sample.
Article in Appetite, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A systematic narrative review of the form, process, and function of sensory hyposensitivity in depression.Translational psychiatry · 2026Pooled it
- Exploring the associations of depressive symptoms with healthy eating self-efficacy over time amongst women in the READI cohort study.The international journal of behavioral nutrition and physical activity · 2021Article
- Adherence to the Australian dietary guidelines and development of depressive symptoms at 5 years follow-up amongst women in the READI cohort study.Nutrition journal · 2020Article
- Sugar intake from sweet food and beverages, common mental disorder and depression: prospective findings from the Whitehall II study.Scientific reports · 2017Article
- A Possible Role of Anhedonia as Common Substrate for Depression and Anxiety.Depression research and treatment · 2016Review
- Preconception Nutrition, Physical Activity, and Birth Outcomes in Adolescent Girls.Journal of pediatric and adolescent gynecology · 2015Article
- Associations between depressive symptoms, self-efficacy, eating styles, exercise and body mass index in women.Journal of behavioral medicine · 2014Article
- Association between the seven-repeat allele of the dopamine-4 receptor gene (DRD4) and spontaneous food intake in pre-school children.Appetite · 2014Article
- Bromocriptine inhibits adipogenesis and lipogenesis by agonistic action on α2-adrenergic receptor in 3T3-L1 adipocyte cells.Molecular biology reports · 2013Article
- Are dopamine-related genotypes risk factors for excessive gestational weight gain?International journal of women's health · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Depression and variation in dopamine related genes have both independently been associated with food consumption. Depressive symptoms could synergistically interact with genetic variation to influence food intake. We examined the interaction between high depressive symptoms and functional polymorphisms of dopamine transporter (SLC6A3), monoamine oxidase A (MAOA), dopamine receptor D2 (DRD2) and dopamine receptor D4 (DRD4) on intake of high-calorie sweet, high-calorie non-sweet, and low-calorie foods in the National Longitudinal Study of Adolescent Health (Add Health). Multivariate linear regression analyses were used to examine main effects of gene and depression symptoms and their interaction (genotype-by-high depression symptoms) on food categories. Applying a false discovery rate criterion for multiple comparisons indicated a statistically significant interaction for females with high depressive symptoms and the SLC6A3 gene, such that those with the SLC6A3 10/10 allele reported greater intake of high-calorie sweet foods than their counterparts high in depressive symptoms with the SLC6A3 any 9 allele (LS mean 10/10 allele=2.5, SE=.13; LS mean any 9 allele=1.8, SE=.13, p<.05). These findings highlight that the relationship between depression and food intake may vary as a function of genetic polymorphism. Further research is needed to confirm these findings.
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