ArticleProgress in biophysics and molecular biology2011
Rabbit-specific ventricular model of cardiac electrophysiological function including specialized conduction system.
Article in Progress in biophysics and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Acute ischaemia and gap junction modulation modify propagation patterns across Purkinje-myocardial junctions.Frontiers in physiology · 2025Article
- Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks.Scientific reports · 2023Article
- Ventricular anatomical complexity and sex differences impact predictions from electrophysiological computational models.PloS one · 2023Article
- Cardiac biophysical detailed synergetic modality rendering and visible correlation.Frontiers in physiology · 2023Article
- Precision medicine in human heart modeling : Perspectives, challenges, and opportunities.Biomechanics and modeling in mechanobiology · 2021Review
- Animal models of arrhythmia: classic electrophysiology to genetically modified large animals.Nature reviews. Cardiology · 2019Review
- Efficient Computational Modeling of Human Ventricular Activation and Its Electrocardiographic Representation: A Sensitivity Study.Cardiovascular engineering and technology · 2018Article
- Predicting the cardiac toxicity of drugs using a novel multiscale exposure-response simulator.Computer methods in biomechanics and biomedical engineering · 2018Article
- Effect of ventricular myocardium characteristics on the defibrillation threshold.Technology and health care : official journal of the European Society for Engineering and Medicine · 2018Article
- Validation and Trustworthiness of Multiscale Models of Cardiac Electrophysiology.Frontiers in physiology · 2018Review
- A quantitative structural and morphometric analysis of the Purkinje network and the Purkinje-myocardial junctions in pig hearts.Journal of anatomy · 2017Article
- Generating Purkinje networks in the human heart.Journal of biomechanics · 2016Article
- Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.Progress in biophysics and molecular biology · 2016Review
- Protective Role of False Tendon in Subjects with Left Bundle Branch Block: A Virtual Population Study.PloS one · 2016Article
- Analysis of Microstructure of the Cardiac Conduction System Based on Three-Dimensional Confocal Microscopy.PloS one · 2016Article
- Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations.Computers in biology and medicine · 2015Review
- Three-dimensional cardiac computational modelling: methods, features and applications.Biomedical engineering online · 2015Review
- Patient-specific generation of the Purkinje network driven by clinical measurements of a normal propagation.Medical & biological engineering & computing · 2014Article
- Images as drivers of progress in cardiac computational modelling.Progress in biophysics and molecular biology · 2014Review
- Simulation Methods and Validation Criteria for Modeling Cardiac Ventricular Electrophysiology.PloS one · 2014Article
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Authors and funding
8 authors.
Funding
Abstract
The function of the ventricular specialized conduction system in the heart is to ensure the coordinated electrical activation of the ventricles. It is therefore critical to the overall function of the heart, and has also been implicated as an important player in various diseases, including lethal ventricular arrhythmias such as ventricular fibrillation and drug-induced torsades de pointes. However, current ventricular models of electrophysiology usually ignore, or include highly simplified representations of the specialized conduction system. Here, we describe the development of an image-based, species-consistent, anatomically-detailed model of rabbit ventricular electrophysiology that incorporates a detailed description of the free-running part of the specialized conduction system. Techniques used for the construction of the geometrical model of the specialized conduction system from a magnetic resonance dataset and integration of the system model into a ventricular anatomical model, developed from the same dataset, are described. Computer simulations of rabbit ventricular electrophysiology are conducted using the novel anatomical model and rabbit-specific membrane kinetics to investigate the importance of the components and properties of the conduction system in determining ventricular function under physiological conditions. Simulation results are compared to panoramic optical mapping experiments for model validation and results interpretation. Full access is provided to the anatomical models developed in this study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.