ArticleThe Journal of clinical psychiatry2011
A prospective, naturalistic, blinded study of early neurobehavioral outcomes for infants following prenatal antidepressant exposure.
Article in The Journal of clinical psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Pooled it
- A systematic review of maternal antidepressant use in pregnancy and short- and long-term offspring's outcomes.Archives of women's mental health · 2018Pooled it
- Neurodevelopmental outcome for offspring of women treated for antenatal depression: a systematic review.Archives of women's mental health · 2014Pooled it
- Maternal use of antidepressant or anxiolytic medication during pregnancy and childhood neurodevelopmental outcomes: a systematic review.European child & adolescent psychiatry · 2014Pooled it
- Preterm birth and antidepressant medication use during pregnancy: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Prenatal Drug Exposure in Children With a History of Neuropsychiatric Care: A Nested Case-Control Study.Frontiers in psychiatry · 2022Article
- Early Developmental Exposure to Fluoxetine and Citalopram Results in Different Neurodevelopmental Outcomes.Neuroscience · 2021Article
- Associations Between Brain Structure and Connectivity in Infants and Exposure to Selective Serotonin Reuptake Inhibitors During Pregnancy.JAMA pediatrics · 2018Article
- The Roles of Maternal Depression, Serotonin Reuptake Inhibitor Treatment, and Concomitant Benzodiazepine Use on Infant Neurobehavioral Functioning Over the First Postnatal Month.The American journal of psychiatry · 2016Article
- Prenatal antidepressant exposure: clinical and preclinical findings.Pharmacological reviews · 2014Review
- Antidepressant use in pregnant and postpartum women.Annual review of clinical psychology · 2014Review
- Central nervous system effects of prenatal selective serotonin reuptake inhibitors: sensing the signal through the noise.Psychopharmacology · 2013Review
- Antidepressant use in pregnancy: a critical review focused on risks and controversies.Acta psychiatrica Scandinavica · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis study examined the potential effects of antidepressant exposure in pregnancy on early infant neurobehavioral outcomes.
methodIn this prospective, naturalistic study, neurobehavioral assessments using the Brazelton Neonatal Behavioral Assessment Scale (BNBAS) were completed by blinded raters between March 2001 and August 2005 on 64 infants who were born to mothers in 1 of 3 categories: (1) women with a history of DSM-IV-diagnosed major depressive disorder (MDD) who were treated with antidepressants during pregnancy, (2) women with a history of DSM-IV-diagnosed MDD who discontinued or chose not to be treated with antidepressants during pregnancy, and (3) a nonpsychiatric control group. Summary scores for the BNBAS were obtained within the first week of life and at 6 to 8 weeks of age.
resultsNo significant differences were observed between groups at either the first week after delivery or at 6 to 8 weeks of age on any of the summary scores for the 7 major clusters of the BNBAS.
conclusionsAntidepressant exposure during pregnancy does not appear to have major adverse effects on indices of early infant neurobehavioral development during the first 2 months of life as assessed by the BNBAS. While this finding is encouraging, further studies with larger samples and longer follow-up are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.