ReviewBirth defects research. Part C, Embryo today : reviews2011
Epigenetics, development, and cancer: zebrafish make their mark..
Review in Birth defects research. Part C, Embryo today : reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- DNA Methylation Dynamics in Development and Disease: Insights from Zebrafish Models.Biomedicines · 2026Review
- Long Term Culture of Germ-Free Zebrafish Using Gamma-Irradiated Feeds.bioRxiv : the preprint server for biology · 2025Article
- A second hit by PFOS exposure exacerbated developmental defects in medaka embryos with a history of ancestral BPA exposure.Chemosphere · 2024Article
- Quantification of DNA Methylation by ELISA in Epigenetic Studies in Plant Tissue Culture: A Theoretical-Practical Guide.Methods in molecular biology (Clifton, N.J.) · 2024Article
- White LED Light Exposure Inhibits the Development and Xanthophore Pigmentation of Zebrafish Embryo.Scientific reports · 2019Article
- Transcriptomics in toxicology.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2017Review
- Atrazine exposure decreases the activity of DNMTs, global DNA methylation levels, and dnmt expression.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2017Article
- Zebrafish as an In Vivo Model to Assess Epigenetic Effects of Ionizing Radiation.International journal of molecular sciences · 2016Review
- Zebrafish Discoveries in Cancer Epigenetics.Advances in experimental medicine and biology · 2016Review
- DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos.Development (Cambridge, England) · 2015Article
- Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases.Clinical epigenetics · 2015Review
- Article
- Hepatic stellate cells in liver development, regeneration, and cancer.The Journal of clinical investigation · 2013Review
- A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation.Disease models & mechanisms · 2013Article
- UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis.Molecular biology of the cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Zebrafish embryos are an exceptional system for studying vertebrate development. Historically, studies using zebrafish to uncover key players in developmentally regulated gene expression have entailed detailed analysis of transcription factors. It is now apparent that epigenetic modifications of both DNA and histone tails are equally important in the regulation of gene expression during development. As such, blocking the function of key epigenetic modifiers impairs development, albeit with surprising tissue specificity. For instance, DNA methylation is an important epigenetic mark that is depleted in embryos lacking dnmt1 and uhrf1. These embryos display developmental defects in the eye, liver, pancreas, and larval lethality. Interestingly, human tumors derived from these same organs have aberrant changes in DNA methylation and altered expression of genes that are thought to contribute to formation of these cancers. These observations have provided a mechanistic basis for treating cancer with drugs that block the enzymes that facilitate DNA and histone modifications. Thus, it is important to understand the consequences of targeting these factors in a whole animal. We review the use of zebrafish for probing the genetic, cellular, and physiological response to alterations in the epigenome and highlight exciting data illustrating that epigenetic studies using zebrafish can inform and impact cancer biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.