ArticleMolecular and cellular biochemistry2011
ES cells overexpressing microRNA-1 attenuate apoptosis in the injured myocardium.
Article in Molecular and cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals.Canadian journal of physiology and pharmacology · 2022Article
- Effects of aerobic and inspiratory training on skeletal muscle microRNA-1 and downstream-associated pathways in patients with heart failure.Journal of cachexia, sarcopenia and muscle · 2020Article
- Novel Mechanisms of Exercise-Induced Cardioprotective Factors in Myocardial Infarction.Frontiers in physiology · 2020Review
- Micromanaging aerobic respiration and glycolysis in cancer cells.Molecular metabolism · 2019Review
- Regulatory non-coding RNAs in acute myocardial infarction.Journal of cellular and molecular medicine · 2017Review
- miRNome in myocardial infarction: Future directions and perspective.World journal of cardiology · 2014Review
- Epigenetic mechanisms underlying cardiac degeneration and regeneration.International journal of cardiology · 2014Review
- CNN3 is regulated by microRNA-1 during muscle development in pigs.International journal of biological sciences · 2014Article
- The potential of stem cells in the treatment of cardiovascular diseases.Stem cell reviews and reports · 2013Review
- Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury.Biochemical and biophysical research communications · 2013Article
- The prediction of the porcine pre-microRNAs in genome-wide based on support vector machine (SVM) and homology searching.BMC genomics · 2012Article
- Insulin ameliorates miR-1-induced injury in H9c2 cells under oxidative stress via Akt activation.Molecular and cellular biochemistry · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
MicroRNAs (miRs) are small, single-stranded, noncoding RNA's involved in post-transcriptional negative gene regulation. Recent investigations have underscored the integral role of miRs in various biological processes including innate immunity, cell-cycle regulation, metabolism, differentiation, and cell death. In the present study, we overexpressed miR-1, a muscle-specific miR, in embryonic stem cells (miR-1-ES cells), transplanted them into the infarcted myocardium, and evaluated their impact on cardiac apoptosis and function. We provide evidence demonstrating reduced apoptosis following transplantation of miR-1-ES cells 4 weeks post-myocardial infarction as compared to respective controls assessed by TUNEL staining and a capsase-3 activity assay. Moreover, we show significant elevation in p-Akt levels and diminished PTEN levels in hearts transplanted with miR-1-ES cells as determined by enzyme-linked immunoassays. Finally, using echocardiography, we reveal mice receiving miR-1-ES cell transplantation post-myocardial infarction had significantly improved fractional shortening and ejection fraction compared with respective controls. Our data suggest transplanted miR-1-ES cells inhibit apoptosis, mediated through the PTEN/Akt pathway, leading to improved cardiac function in the infarcted myocardium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.