ArticleCurrent psychiatry reports2011
Inflammatory biomarkers in depression: an opportunity for novel therapeutic interventions.
Article in Current psychiatry reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Inflammatory Parameters in Patients with Suicide Attempts by Drug Overdose: A Comparative Study with a Comparison Group.Medicina (Kaunas, Lithuania) · 2026Observational
- The impact and mechanisms of YL-IPA08, a potent ligand for the translocator protein (18 kDa) on protection against LPS-induced depression and cognitive dysfunction in rodents.Metabolic brain disease · 2025Article
- Kif15 deficiency contributes to depression-like behavior in mice.Metabolic brain disease · 2023Article
- Anti-Inflammatory Therapy as a Promising Target in Neuropsychiatric Disorders.Advances in experimental medicine and biology · 2023Review
- Article
- Biomarkers of Major Depressive Disorder: Knowing is Half the Battle.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021Review
- Depression in Psoriatic Arthritis: Dimensional Aspects and Link with Systemic Inflammation.Rheumatology and therapy · 2020Review
- NLRP1-Mediated Antidepressant Effect of Ketamine in Chronic Unpredictable Mild Stress Model in Rats.Psychiatry investigation · 2020Article
- Plasma and cerebrospinal fluid inflammatory cytokines in perinatal depression.American journal of obstetrics and gynecology · 2019Observational
- The Metabolic Factor Kynurenic Acid of Kynurenine Pathway Predicts Major Depressive Disorder.Frontiers in psychiatry · 2018Article
- Cytokines and depression in cancer patients and caregivers.Neuropsychiatric disease and treatment · 2017Article
- Reelin-Related Disturbances in Depression: Implications for Translational Studies.Frontiers in cellular neuroscience · 2016Review
- The potential of biomarkers in psychiatry: focus on proteomics.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- Antidepressant-like effect of celecoxib piroxicam in rat models of depression.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- From stress to inflammation and major depressive disorder: a social signal transduction theory of depression.Psychological bulletin · 2014Review
- The neurobiological pathogenesis of poststroke depression.TheScientificWorldJournal · 2014Review
- Dysregulated diurnal cortisol pattern is associated with glucocorticoid resistance in women with major depressive disorder.Biological psychology · 2013Article
- The mechanism of antidepressant-like effects of piroxicam in rats.Journal of pharmacology & pharmacotherapeuticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently available antidepressants are effective in less than two thirds of depressed patients, with even lower remission rates in the context of co-morbid medical illness. A rapidly expanding evidence base suggests that maladaptive inflammatory immune responses may be a common pathophysiology underlying depression, particularly in the presence of a general medical condition. The inflammatory hypothesis of depression marks a significant shift away from monoamine-based approaches and is a major step towards developing novel treatments that directly target causal factors of depression. Many antidepressants exert anti-inflammatory effects and there is an emerging literature documenting the efficacy of anti-inflammatory agents as adjunctive treatments for depression. Identification of inflammatory biomarkers in depression will require a re-conceptualization of both the diagnostic phenomenology and the experimental approaches to studying multi-determined psychiatric disorders. In addition to their application in diagnosis, predicting prognosis, and monitoring severity and response to treatment, inflammatory biomarkers may serve as novel therapeutic targets in the treatment of depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.