ArticleMolecular biology reports2012
DNA repair genes polymorphism (XPG and XRCC1) and association of prostate cancer in a north Indian population.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 8 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 8 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Associations between XRCC1-Arg399Gln polymorphism and the risk of prostate cancer: an updated meta-analysis.Amino acids · 2025Pooled it
- Pooled it
- Association Between Twelve Polymorphisms in Five X-ray Repair Cross-complementing Genes and the Risk of Urological Neoplasms: A Systematic Review and Meta-Analysis.EBioMedicine · 2017Pooled it
- Meta-Analysis of the Relationship between XRCC1-Arg399Gln and Arg280His Polymorphisms and the Risk of Prostate Cancer.Scientific reports · 2015Pooled it
- Systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men.European urology · 2014Pooled it
- Association between the XPG Asp1104His and XPF Arg415Gln polymorphisms and risk of cancer: a meta-analysis.PloS one · 2014Pooled it
- A functional polymorphism in XRCC1 is associated with glioma risk: evidence from a meta-analysis.Molecular biology reports · 2013Pooled it
- Association between the ERCC5 Asp1104His polymorphism and cancer risk: a meta-analysis.PloS one · 2012Pooled it
- The Role of DNA Repair (Medicina (Kaunas, Lithuania) · 2024Article
- Association ofClinical and experimental gastroenterology · 2020Article
- Genetic Variant Arg399Gln G>A of XRCC1 DNA Repair Gene Enhanced Cancer Risk Among Indian Population: Evidence from Meta-analysis and Trial Sequence Analyses.Indian journal of clinical biochemistry : IJCB · 2018Article
- Polymorphisms inJournal of Cancer · 2018Article
- Influence of XPC, XPD, XPF, and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Article
- Association between X-ray repair cross-complementing group 1 gene polymorphisms and glioma risk: a systematic review and meta-analysis based on 22 case-control studies.International journal of clinical and experimental medicine · 2015Review
- Association study between XPG Asp1104His polymorphism and colorectal cancer risk in a Chinese population.Scientific reports · 2014Article
- Three polymorphisms of DNA repair gene XRCC1 and the risk of glioma: a case-control study in northwest China.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Allele and genotype distributions of DNA repair gene polymorphisms in South Indian healthy population.Biomarkers in cancer · 2014Article
- Expression of XPG protein in human normal and tumor tissues.International journal of clinical and experimental pathology · 2013Article
- DNA repair XRCC1 Arg399Gln polymorphism is associated with the risk of development of end-stage renal disease.Molecular biology reports · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostate cancer is the most commonly diagnosed cancer in men worldwide and is the second leading cause of cancer related mortality. Genetic background may account for the difference in susceptibility of individuals to different diseases and the relationship between genetic polymorphism and some diseases has been extensively studied. There are several common polymorphisms in genes encoding DNA repair enzymes, some of these polymorphisms are reported to result in subtle structural alterations of the repair enzyme and modulation of the repair capacity. The aim of the present study was to analyze the effect of XPG Asp 1104His and XRCC1 Arg309Gln polymorphisms on risk of prostate cancer in north Indian population. Statistically significant increased risk of prostate cancer was observed on individuals that posses His/His genotype of XPG (OR 2.53, 95% CI 0.99-6.56, P = 0.031). In this study 150 prostate cancer diagnosed patients, 150 healthy controls and 150 BPH (benign prostate hyper plasia) were recruited from north Indian population. Moreover, individuals that carried the Gln/Gln genotype of XRCC1 also showed statistically increased risk of prostate cancer (OR 2.06, 95% CI 1.07-4.00, P = 0.033). The Asp/Asp of XPG and Gln/Gln of XRCC1 in combination showed statistically increased risk of prostate cancer in cases (OR 3.29, 95% CI 1.09-10.16, P = 0.032).
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