ArticleHypertension (Dallas, Tex. : 1979)2011
Relationship between urinary angiotensinogen and salt sensitivity of blood pressure in patients with IgA nephropathy.
Article in Hypertension (Dallas, Tex. : 1979), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Non-immunosuppressive treatment for IgA nephropathy.The Cochrane database of systematic reviews · 2024Pooled it
- Altered dietary salt intake for people with chronic kidney disease.The Cochrane database of systematic reviews · 2021Pooled it
- Sodium balance, circadian BP rhythm, heart rate variability, and intrarenal renin-angiotensin-aldosterone and dopaminergic systems in acute phase of ARB therapy.Physiological reports · 2017Trial
- Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial.Clinical and experimental nephrology · 2015Trial
- A randomized trial of dietary sodium restriction in CKD.Journal of the American Society of Nephrology : JASN · 2013Trial
- The angiotensin II type 1 receptor blocker olmesartan preferentially improves nocturnal hypertension and proteinuria in chronic kidney disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2013Trial
- Epigenetic Regulation of Innate and Adaptive Immune Cells in Salt-Sensitive Hypertension.Circulation research · 2025Review
- Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting.Pharmacological reviews · 2022Review
- Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Review
- Independent regulation of renin-angiotensin-aldosterone system in the kidney.Clinical and experimental nephrology · 2018Review
- Circadian regulation of kidney function: finding a role for Bmal1.American journal of physiology. Renal physiology · 2018Review
- Effects of Olmesartan and Azilsartan on Albuminuria and the Intrarenal Renin-Angiotensin System.World journal of research and review · 2018Article
- Effects of sodium-glucose cotransporter 2 inhibitors on urinary excretion of intact and total angiotensinogen in patients with type 2 diabetes.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2017Article
- Circadian rhythm of blood pressure and the renin-angiotensin system in the kidney.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Review
- Relationship between blood pressure variability and renal activity of the renin-angiotensin system.Journal of human hypertension · 2016Article
- Renal Dysfunction, Rather Than Nonrenal Vascular Dysfunction, Mediates Salt-Induced Hypertension.Circulation · 2016Article
- Evaluation of kidney dysfunction and angiotensinogen as an early novel biomarker of intrauterine growth restricted offspring rats.Pediatric research · 2015Article
- Hypertension in Chronic Glomerulonephritis.Electrolyte & blood pressure : E & BP · 2015Review
- Urine angiotensinogen and salt-sensitivity and potassium-sensitivity of blood pressure.Journal of hypertension · 2015Article
- A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression.Journal of the American Society of Nephrology : JASN · 2015Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
We demonstrated previously that the blood pressure of patients with IgA nephropathy becomes salt sensitive as renal damage progresses. We also showed that increased urinary angiotensinogen levels in such patients closely correlate with augmented renal tissue angiotensinogen gene expression and angiotensin II levels. Here, we investigated the relationship between urinary angiotensinogen and salt sensitivity of blood pressure in patients with IgA nephropathy. Forty-one patients with IgA nephropathy consumed an ordinary salt diet (12 g/d of NaCl) for 1 week and a low-salt diet (5 g/d of NaCl) for 1 week in random order. The salt-sensitivity index was calculated as the reciprocal of the slope of the pressure-natriuresis curve drawn by linking 2 data points obtained during consumption of each diet. The urinary angiotensinogen:creatinine ratio was significantly higher in patients who consumed the ordinary salt diet compared with the low-salt diet (17.5 μg/g [range: 7.3 to 35.6 μg/g] versus 7.9 μg/g [range: 3.1 to 14.2 μg/g] of creatinine, respectively; P<0.001). The sodium sensitivity index in our patients positively correlated with the glomerulosclerosis score (r=0.43; P=0.008) and changes in logarithmic urinary angiotensinogen:creatinine ratio (r=0.37; P=0.017) but not with changes in urinary protein excretion (r=0.18; P=0.49). In contrast, changes in sodium intake did not alter the urinary angiotensinogen:creatinine ratio in patients with Ménière disease and normal renal function (n=9). These data suggest that the inappropriate augmentation of intrarenal angiotensinogen induced by salt and associated renal damage contribute to the development of salt-sensitive hypertension in patients with IgA nephropathy.
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