ArticleProceedings of the National Academy of Sciences of the United States of America2011
Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- The chromatin reader Dido3 is a regulator of the gene network that controls B cell differentiation.Cell & bioscience · 2025Article
- The Ig heavy chain protein but not its message controls early B cell development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- IgH isotype-specific B cell receptor expression influences B cell fate.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mechanisms of central tolerance for B cells.Nature reviews. Immunology · 2017Review
- A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production.The Journal of experimental medicine · 2016Article
- CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.The Journal of experimental medicine · 2015Article
- Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Clinical observations on chemotherapy curable malignancies: unique genetic events, frozen development and enduring apoptotic potential.BMC cancer · 2015Article
- Long-Range Regulation of V(D)J Recombination.Advances in immunology · 2015Review
- Independent recruitment of Igh alleles in V(D)J recombination.Nature communications · 2014Article
- Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.Immunology · 2013Review
- Inhibition of nonsense-mediated RNA decay activates autophagy.Molecular and cellular biology · 2013Article
- A Novel Quantitative Fluorescent Reporter Assay for RAG Targets and RAG Activity.Frontiers in immunology · 2013Article
- Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development.Molecular and cellular biology · 2012Article
- Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
B-lymphocyte development is dictated by the protein products of functionally rearranged Ig heavy (H) and light (L) chain genes. Ig rearrangement begins in pro-B cells at the IgH locus. If pro-B cells generate a productive allele, they assemble a pre-B cell receptor complex, which signals their differentiation into pre-B cells and their clonal expansion. Pre-B cell receptor signals are also thought to contribute to allelic exclusion by preventing further IgH rearrangements. Here we show in two independent mouse models that the accumulation of a stabilized μH mRNA that does not encode μH chain protein specifically impairs pro-B cell differentiation and reduces the frequency of rearranged IgH genes in a dose-dependent manner. Because noncoding IgH mRNA is usually rapidly degraded by the nonsense-mediated mRNA decay machinery, we propose that the difference in mRNA stability allows pro-B cells to distinguish between productive and nonproductive Ig gene rearrangements and that μH mRNA may thus contribute to efficient H chain allelic exclusion.
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