ArticleProceedings of the National Academy of Sciences of the United States of America2011
MicroRNA-mediated posttranscriptional regulation is required for maintaining undifferentiated properties of blastoderm and primordial germ cells in chickens.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 81 citations in OpenAlex.
- Article
- Review
- Formation, Application, and Significance of Chicken Primordial Germ Cells: A Review.Animals : an open access journal from MDPI · 2023Review
- Review
- - Invited Review - Gene-editing techniques and their applications in livestock and beyond.Animal bioscience · 2023Article
- Identification of chicken LOC420478 as Bucky ball equivalent and potential germ plasm organizer in birds.Scientific reports · 2022Article
- Chicken blastoderms and primordial germ cells possess a higher expression of DNA repair genes and lower expression of apoptosis genes to preserve their genome stability.Scientific reports · 2022Article
- Effect of miR-302b MicroRNA Inhibition on Chicken Primordial Germ Cell Proliferation and Apoptosis Rate.Genes · 2021Article
- Article
- Zygotic genome activation in the chicken: a comparative review.Cellular and molecular life sciences : CMLS · 2020Review
- Comprehensive analysis of miRNAs, lncRNAs, and mRNAs reveals potential players of sexually dimorphic and left-right asymmetry in chicken gonad during gonadal differentiation.Poultry science · 2020Article
- Interdigital tissue remodelling in the embryonic limb involves dynamic regulation of the miRNA profiles.Journal of anatomy · 2017Article
- High-throughput sequencing of pituitary and hypothalamic microRNA transcriptome associated with high rate of egg production.BMC genomics · 2017Article
- Article
- Regulatory elements and transcriptional control of chickenJournal of animal science and biotechnology · 2017Article
- The avian-specific small heat shock protein HSP25 is a constitutive protector against environmental stresses during blastoderm dormancy.Scientific reports · 2016Article
- Wnt/β-catenin signaling pathway activation is required for proliferation of chicken primordial germ cells in vitro.Scientific reports · 2016Article
- Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring.Translational psychiatry · 2016Article
- MicroRNAs: From Female Fertility, Germ Cells, and Stem Cells to Cancer in Humans.Stem cells international · 2016Review
- PGC-Enriched miRNAs Control Germ Cell Development.Molecules and cells · 2015Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) play a critical role in determining the differentiation fate of pluripotent stem cells and germ cells in mammals. However, the mechanism(s) of miRNA-mediated posttranscriptional regulation with regard to lineage specification and differentiation in chick development require further investigation. Therefore, we conducted miRNA expression profiling to explore specific miRNA signatures in undifferentiated blastoderm and primordial germ cells (PGCs). We identified seven miRNAs that are highly expressed in blastoderm and 10 that are highly expressed in PGCs. In this study, miR-302a and miR-456 for blastoderm and miR-181a* for PGCs were analyzed further for their target transcripts and regulatory pathways. Both miR-302a and miR-456 bound directly to the sex-determining region Y box 11 transcript and could act as posttranscriptional coregulators to maintain the undifferentiated state of the chicken blastoderm through the suppression of somatic gene expression and differentiation. Moreover, miR-181a* showed a bifunctional role in PGCs by binding to two different transcripts. miR-181a* inhibited the somatic differentiation of PGCs by silencing homeobox A1 expression. Additionally, miR-181a* prevented PGCs from entering meiosis through the repression of the nuclear receptor subfamily 6, group A, member 1 transcript. Collectively, our data demonstrate that in chickens miRNAs intrinsically regulate the differentiation fate of blastoderms and PGCs and that the specific timing of germ cell meiosis is controlled through miRNA expression.
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