ArticleThe Journal of experimental medicine2011
Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth.
Article in The Journal of experimental medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 66 citations in OpenAlex.
- The Tumor Immune Microenvironment Architecture Correlates with Risk of Recurrence in Head and Neck Squamous Cell Carcinoma.Cancer research · 2023Article
- Article
- AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data.Nature communications · 2021Article
- Inhibition of Orthotopic Genital Cancer Induced by Subcutaneous Administration of Human Papillomavirus Peptide Vaccine with CpG Oligodeoxynucleotides as an Adjuvant in Mice.Cancer management and research · 2021Article
- Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.The Journal of pathology · 2020Article
- Review
- The regulation of immune tolerance by FOXP3.Nature reviews. Immunology · 2017Review
- FoxP3 Expression in Macrophages, Cancer, and B Cells-Is It Real?Clinical reviews in allergy & immunology · 2017Review
- CD200R/Foxp3-mediated signalling regulates microglial activation.Scientific reports · 2016Article
- Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses.European journal of immunology · 2016Article
- High and low molecular weight hyaluronic acid differentially influence macrophage activation.ACS biomaterials science & engineering · 2015Article
- Harnessing immunosurveillance: current developments and future directions in cancer immunotherapy.ImmunoTargets and therapy · 2014Review
- Changes in adipose tissue macrophages and T cells during aging.Critical reviews in immunology · 2014Review
- Article
- Genetic polymorphism in FOXP3 gene: imbalance in regulatory T-cell role and development of human diseases.Journal of genetics · 2013Review
- PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.PloS one · 2013Article
- CD19(+) B cells confer protection against experimental cerebral malaria in semi-immune rodent model.PloS one · 2013Article
- Autofluorescence contributes to false-positive intracellular Foxp3 staining in macrophages: a lesson learned from flow cytometry.Journal of immunological methods · 2012Article
- Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP.European journal of immunology · 2012Article
- The Mycobacterium tuberculosis stress response factor SigH is required for bacterial burden as well as immunopathology in primate lungs.The Journal of infectious diseases · 2012Article
Corrections and comments
- Retraction · 2011-11-14Concerns/Issues about Data · Investigation by Company/Institution · Objections by Third Party · Results Not Reproducible ·
- Commented on by
- Commented on by
- Commented on by
- Retracted
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Regulatory T cells (T reg cells) are characterized by the expression of the forkhead lineage-specific transcription factor Foxp3, and their main function is to suppress T cells. While evaluating T reg cells, we identified a population of Foxp3-positive cells that were CD11b(+)F4/80(+)CD68(+), indicating macrophage origin. These cells were observed in spleen, lymph nodes, bone marrow, thymus, liver, and other tissues of naive animals. To characterize this subpopulation of macrophages, we devised a strategy to purify CD11b(+)F4/80(+)Foxp3(+) macrophages using Foxp3-GFP mice. Analysis of CD11b(+)F4/80(+)Foxp3(+) macrophage function indicated that these cells inhibited the proliferation of T cells, whereas Foxp3(-) macrophages did not. Suppression of T cell proliferation was mediated through soluble factors. Foxp3(-) macrophages acquired Foxp3 expression after activation, which conferred inhibitory properties that were indistinguishable from natural Foxp3(+) macrophages. The cytokine and transcriptional profiles of Foxp3(+) macrophages were distinct from those of Foxp3(-) macrophages, indicating that these cells have different biological functions. Functional in vivo analyses indicated that CD11b(+)F4/80(+)Foxp3(+) macrophages are important in tumor promotion and the induction of T reg cell conversion. For the first time, these studies demonstrate the existence of a distinct subpopulation of naturally occurring macrophage regulatory cells in which expression of Foxp3 correlates with suppressive function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.