Evidence map›Paper›PMID 21670160›Full record

ReviewPhysiology (Bethesda, Md.)2011

Vascular effects of exercise: endothelial adaptations beyond active muscle beds.

Jaume Padilla, Grant H Simmons, Shawn B Bender, Arturo A Arce-Esquivel, Jeffrey J Whyte, M Harold Laughlin

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Exercise and Circulating Microparticles in Healthy Subjects.Journal of cardiovascular translational research · 2021
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Review
  17. The Effects of Physical Activity on Skin Health: A Narrative Review.Clinical, cosmetic and investigational dermatology · 2025
    Review
  18. Article
  19. Article
  20. Article

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jaume PadillaBiomedical Sciences, University of Missouri, Columbia, Missouri, USA. laughlinM@missouri.edu
Grant H Simmons
Shawn B Bender
Arturo A Arce-Esquivel
Jeffrey J Whyte
M Harold Laughlin

Funding

Vascular Biology: Exercise Training and Vascular DiseaseP01HL052490 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LAUGHLIN, M HAROLD · 1995 to 2010
$19.3M
TRAINING: MUSCLE BLOOD FLOW &CAPILLARY DYNAMICSR01HL036088 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LAUGHLIN, M HAROLD · 1985 to 2013
$4.0M
Exercise &Health: Integration from Molecule to PatientT32AR048523 · NIAMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI TERJUNG, RONALD L · 2003 to 2013
$2.5M
NHLBI NIH HHS HL-36088NHLBI NIH HHS P01 HL052490NHLBI NIH HHS P01-HL-052490NHLBI NIH HHS R01 HL036088NIAMS NIH HHS T32 AR048523NIAMS NIH HHS T32-AR-048523
6 · The paper itself

Abstract

Endothelial adaptations to exercise training are not exclusively conferred within the active muscle beds. Herein, we summarize key studies that have evaluated the impact of chronic exercise on the endothelium of vasculatures perfusing nonworking skeletal muscle, brain, viscera, and skin, concluding with discussion of potential mechanisms driving these endothelial adaptations.

Indexed as

ExerciseHemodynamicsMuscle ContractionAdaptation, PhysiologicalAnimalsCerebrovascular CirculationEndothelium, VascularHumansMuscle, SkeletalRenal CirculationSignal TransductionSkinSplanchnic Circulation

Identifiers

PMID21670160
PMCPMC3286126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.