ArticleMolecular and cellular biology2011
Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- TLN1 interacts with NGFR and suppresses the development of castration-resistant prostate cancer by upregulating NGFR.Frontiers in immunology · 2026Article
- Kindlin-2 Deletion in Mural Cells Leads to Vascular Instability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Identification of novel nutrient sensitive human yolk sac functions required for embryogenesis.Scientific reports · 2024Article
- TLN1: an oncogene associated with tumorigenesis and progression.Discover oncology · 2024Review
- PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1.Scientific reports · 2020Article
- PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- miR-429 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by downregulation of TLN1.Cancer cell international · 2019Article
- Cell-Surface Glyco-Engineering by Exogenous Enzymatic Transfer Using a Bifunctional CMP-Neu5Ac Derivative.Journal of the American Chemical Society · 2017Article
- Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt.PloS one · 2017Article
- Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation.The Journal of cell biology · 2016Article
- Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.Nature communications · 2016Article
- PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation.Cell death and differentiation · 2015Article
- A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells.Journal of cell science · 2014Article
- The fate of internalized α5 integrin is regulated by matrix-capable fibronectin.The Journal of surgical research · 2014Article
- Mechanisms of talin-dependent integrin signaling and crosstalk.Biochimica et biophysica acta · 2014Review
- 14-3-3θ facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels.Journal of cell science · 2014Article
- Talins and kindlins: partners in integrin-mediated adhesion.Nature reviews. Molecular cell biology · 2013Review
- Article
- Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.Biochemical and biophysical research communications · 2012Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Talin is a cytoskeletal protein that binds to integrin β cytoplasmic tails and regulates integrin activation. Talin1 ablation in mice disrupts gastrulation and causes embryonic lethality. However, the role of talin in mammalian epithelial morphogenesis is poorly understood. Here we demonstrate that embryoid bodies (EBs) differentiated from talin1-null embryonic stem cells are defective in integrin adhesion complex assembly, epiblast elongation, and lineage differentiation. These defects are accompanied by a significant reduction in integrin β1 protein levels due to accelerated degradation through an MG-132-sensitive proteasomal pathway. Overexpression of integrin β1 or MG-132 treatment in mutant EBs largely rescues the phenotype. In addition, epiblast cells isolated from talin1-null EBs exhibit impaired cell spreading and focal adhesion formation. Transfection of the mutant cells with green fluorescent protein (GFP)-tagged wild-type but not mutant talin1 that is defective in integrin binding normalizes integrin β1 protein levels and restores focal adhesion formation. Significantly, cell adhesion and spreading are also improved by overexpression of integrin β1. All together, these results suggest that talin1 binding to integrin promotes epiblast adhesion and morphogenesis in part by preventing integrin β1 degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.