ReviewDisease models & mechanisms2011
Worms, flies and four-legged friends: the applicability of biological models to the understanding of intestinal inflammatory diseases.
Review in Disease models & mechanisms, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- The Relevance of Experimental Models in Assessing the Impact of Oxidative Stress on Intestinal Pathology.Journal of clinical medicine · 2025Review
- Drosophila melanogaster models for investigating inflammatory bowel disease: Methods, pathology, mechanisms, and therapeutic approaches.Biomolecules & biomedicine · 2025Review
- Reducing dextran sodium sulfate interference with gene expression quantification in a mouse model of colitis.Journal of animal science · 2025Article
- Extracts ofHylotelephiumerythrostictum (miq.) H. Ohba ameliorate intestinal injury by scavenging ROS and inhibiting multiple signaling pathways in Drosophila.BMC complementary medicine and therapies · 2024Article
- Animal models of inflammatory bowel disease: category and evaluation indexes.Gastroenterology report · 2024Review
- Nutritional, molecular, and functional properties of a novel enzymatically hydrolyzed porcine plasma product.PloS one · 2024Article
- UsingFrontiers in pharmacology · 2022Review
- Human small intestinal organotypic culture model for drug permeation, inflammation, and toxicity assays.In vitro cellular & developmental biology. Animal · 2021Review
- Caenorhabditis elegans: a model to understand host-microbe interactions.Cellular and molecular life sciences : CMLS · 2020Review
- Effects of Dietary Grape Seed Meal Bioactive Compounds on the Colonic Microbiota of Weaned Piglets With Dextran Sodium Sulfate-Induced Colitis Used as an Inflammatory Model.Frontiers in veterinary science · 2020Article
- Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster.PLoS genetics · 2018Article
- Model organism data evolving in support of translational medicine.Lab animal · 2018Review
- Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis.Pediatric research · 2018Article
- Extracellular Vesicles From the HelminthFrontiers in microbiology · 2018Article
- DNA duplication is essential for the repair of gastrointestinal perforation in the insect midgut.Scientific reports · 2016Article
- Animal models to study acute and chronic intestinal inflammation in mammals.Gut pathogens · 2015Review
- Epidemiological and clinical characteristics of inflammatory bowel diseases in Cairo, Egypt.World journal of gastroenterology · 2014Article
- Drosophila as a model to study the role of blood cells in inflammation, innate immunity and cancer.Frontiers in cellular and infection microbiology · 2014Review
- Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans.EMBO molecular medicine · 2013Review
- Animal models of ulcerative colitis and their application in drug research.Drug design, development and therapy · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Diseases of intestinal inflammation, including Crohn's disease, ulcerative colitis and necrotizing enterocolitis, cause substantial acute and chronic disability in a large proportion of the population. Crohn's disease and ulcerative colitis, which are collectively referred to as inflammatory bowel disease (IBD), lead to recurrent episodes of intestinal dysfunction and systemic illness, whereas necrotizing enterocolitis is characterized by the development of dramatic and all too often fatal intestinal necrosis in infants. To determine the molecular underpinnings of these disorders, investigators have explored a variety of animal models that vary widely in their complexity. These experimental systems include the invertebrate nematode Caenorhabditis elegans, the more complex invertebrate Drosophila melanogaster, and vertebrate systems including mice, rats and other mammals. This review explores the experimental models that are used to mimic and evaluate the pathogenic mechanisms leading to these diseases of intestinal inflammation. We then highlight, as an example, how the use of different experimental models that focus on the role of Toll-like receptor 4 (TLR4) signaling in the gut has revealed important distinctions between the pathogenesis of IBD and necrotizing enterocolitis. Specifically, TLR4-mediated signaling plays a protective role in the development of Crohn's disease and ulcerative colitis, whereas this signaling pathway plays a causative role in the development of necrotizing enterocolitis in the newborn small intestine by adversely affecting intestinal injury and repair mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.