ReviewDisease models & mechanisms2011
Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias.
Review in Disease models & mechanisms, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 64 citations in OpenAlex.
- Molecular traces of Drosophila hemocytes reveal transcriptomic conservation with vertebrate myeloid cells.PLoS genetics · 2023Article
- Single-cell transcriptomics identifies new blood cell populations in Drosophila released at the onset of metamorphosis.Development (Cambridge, England) · 2023Article
- Intrinsic and Extrinsic Regulation of Hematopoiesis inMolecules and cells · 2022Review
- Inhibition of kinase IKKβ suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6.Scientific reports · 2021Article
- The Roles of the LIM Domain Proteins inFrontiers in cardiovascular medicine · 2021Review
- Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila.Nature communications · 2020Article
- A Receptor Guanylate Cyclase, Gyc76C, Mediates Humoral, and Cellular Responses in Distinct Ways inFrontiers in immunology · 2020Article
- The Posterior Signaling Center Is an Important Microenvironment for Homeostasis of theFrontiers in cell and developmental biology · 2020Review
- Beadex, a homologue of the vertebrate LIM domain only protein, is a novel regulator of crystal cell development inJournal of genetics · 2019Article
- Drosophila as a Model for Tumor-Induced Organ Wasting.Advances in experimental medicine and biology · 2019Review
- Hedgehog signaling from the Posterior Signaling Center maintains U-shaped expression and a prohemocyte population in Drosophila.Developmental biology · 2018Article
- Modulation of occluding junctions alters the hematopoietic niche to trigger immune activation.eLife · 2017Article
- A Genetic Screen Reveals an Unexpected Role for Yorkie Signaling in JAK/STAT-Dependent Hematopoietic Malignancies inG3 (Bethesda, Md.) · 2017Article
- The Immune Phenotype of ThreeG3 (Bethesda, Md.) · 2017Article
- The matrix protein Tiggrin regulates plasmatocyte maturation inDevelopment (Cambridge, England) · 2017Article
- Article
- Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly.Developmental cell · 2017Review
- Methods to Examine the Lymph Gland and Hemocytes in Drosophila Larvae.Journal of visualized experiments : JoVE · 2016Article
- The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells.Oncotarget · 2016Article
- Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection.PLoS pathogens · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrate haematopoietic stem cells (HSCs) give rise to a hierarchically organised set of progenitors for erythroid, myeloid, lymphoid and megakaryocyte lineages, and are responsible for lifelong maintenance of the blood system. Dysregulation of the haematopoietic differentiation programme is at the origin of numerous pathologies, including leukaemias. With the discoveries that many transcriptional regulators and signalling pathways controlling blood cell development are conserved between humans and Drosophila melanogaster, the fruit fly has become a good model for investigating the mechanisms underlying the generation of blood cell lineages and blood cell homeostasis. In this review article, we discuss how genetic and molecular studies of Drosophila haematopoiesis can contribute to our understanding of the haematopoietic niche, as well as of the origin and/or progression of haematopoietic malignancies in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.