ArticleIntegrative and comparative biology2008
Anterior-posterior patterning and segmentation of the vertebrate head.
Article in Integrative and comparative biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Unravelling the progression of the zebrafish primary body axis with reconstructed spatiotemporal transcriptomics.Genome biology · 2026Article
- A Spacetime Odyssey of Neural Progenitors to Generate Neuronal Diversity.Neuroscience bulletin · 2023Review
- Early Wnt Signaling Activation Promotes Inner Ear Differentiation via Cell Caudalization in Mouse Stem Cell-Derived Organoids.Stem cells (Dayton, Ohio) · 2023Article
- Variations in maternal vitamin A intake modifies phenotypes in a mouse model of 22q11.2 deletion syndrome.Birth defects research · 2020Article
- Recent Advancements in Engineering Strategies for Manipulating Neural Stem Cell Behavior.Current tissue microenvironment reports · 2020Article
- Oral and Palatal Dentition of Axolotl Arises From a Common Tooth-Competent Zone Along the Ecto-Endodermal Boundary.Frontiers in cell and developmental biology · 2020Article
- Bichir external gills arise via heterochronic shift that accelerates hyoid arch development.eLife · 2019Article
- A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons.Developmental biology · 2016Article
- BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis.Nature communications · 2016Article
- Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes.Seminars in cell & developmental biology · 2015Review
- How cells know where they are.Science (New York, N.Y.) · 2013Review
- Expression and retinoic acid regulation of the zebrafish nr2f orphan nuclear receptor genes.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Segmentation of the vertebrate head emerges out of earlier processes that establish the anterior-posterior (A-P) axis. Recent genetic studies and comparisons across species have led to a better understanding of the links between A-P patterning and segmentation. These point to similar signals acting on both head and trunk, such as retinoic acid and fibroblast growth factors. These form interacting networks of diffusible morphogen gradients that pattern both hindbrain rhombomeres and mesodermal somites. New computational models, particularly for retinoic acid, have revealed how morphogen gradients are established and made robust to changes in signaling levels. However, the orientations of these gradients, as well as how they interact to generate segments, differ remarkably between germ layers and body regions. Thus, the vertebrate head is, in part, built through modifications of the same processes that link A-P patterning and segmentation in the trunk, but fundamental differences in how these processes are deployed lend further doubt to the notion that head and trunk segments are homologous.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.